Talk:Insulin receptor

Insulin in cells
Actually a large proprtion of the circulating is removed by receptor mediated endocytosis. So there is a pretty good reason for insulin being in cells. Just not the one that the author was aluding to (see comments to revision of 01:54, 21 August 2006). Ianmc 20:25, 23 August 2006 (UTC)
 * nah, the internalized insulin bound to the receptor is degraded and the receptor recycled (reactome.org). --Ayacop (talk) 18:14, 29 November 2008 (UTC)

so where does it continue?
the article: This protein then begins a phosphorylation cascade, culminating in the activation of mitogen-activated protein kinase (MAPK), which enters the nucleus and phosphorylates various nuclear transcription factors (such as Elk1).

and so what? what does elk1 do? enhance transcription in general or specifically? why? --Ayacop (talk) 18:12, 29 November 2008 (UTC)

Genetic Variant Near IRS1 Associated With T2DM, Insulin Resistance and Hyperinsulinemia
Would it be a good idea to something about this recent discovery: Science Daily Nature Genetics

"It's a single-nucleotide polymorphism (SNP, pronounced 'snip'), a single letter change in your DNA," said Sladek. "What's interesting about this particular SNP is that it's not linked genetically to the IRS1 gene in any way; it's about half-a-million base-pairs away, in the middle of a genetic desert with no known genes nearby. In genetic terms, it's halfway from Montreal to Halifax. And yet we can see that it causes a 40-per-cent reduction in the IRS1 gene, and even more important, a 40-per-cent reduction in its activity. Which means that even if insulin is present, it won't work."

About to add some major edits.
In the interests of full disclosure im a research assistant (BSc, Hons) working in the Lawrence lab at Walter and Eliza Hall Institute of Medicine (WEHI) and this will be the first time i edit a wikipedia page.

Our group has published structures (already referenced in the wiki - not by us) of T2DM and 3LOH of the IR. It is apparent to us that this wikipedia page is incomplete in terms of introductory detail, structural information, relevant referencing and aesthetic flow. I do not aim to remove information, only improve its readability and add some peer reviewed support to arguments or assertions lacking so.

Audience: Although im sure many lay people primarily or otherwise affected by diabetes look for details in the wikipedia page, im more certain that those accessing the page specifically on the IR are after more scientifically comprehensive subject matter and thus assume that using basic scientific descriptives would be beneficial. That said, i will attempt to link back to other wiki articles so that those from varying fields, or those trying to educate themselfs on the details of the IR can do so in an 'single -click' manor.

If there is any disagreement to my assessment of audience than please let me know.- Fletcher01 15/02/12