Talk:Linezolid

Comments
It is not the only antibiotic that inhibits protein synthesis but it is the most efficient one. There are certain strains that cannot be inhibited by any other antibiotic. —Preceding unsigned comment added by 62.1.218.193 (talk) 16:11, 27 September 2007 (UTC)

Are you sure that this is the only antibiotic that works by inhibiting protein synthesis? Macrolides, aminoglycosides, chloramphenicol, and tetracycline are all protein synthesis inhibitors, not just linezolid.

Streptogramins too, but these generally inhibit protein elongation, not initiation, I think

The scientific meaning of antibiotic is that it is a natural product produced by some fungi (living system). This may be then completely synthesized as the case with chloramphenicol. Actually I didn't find any literature that discussed linezolid natural production; so I prefere to categorize it as an antibacterial rather than antibiotic as in case of quinolones. — Preceding unsigned comment added by 41.34.125.138 (talk) 22:12, 26 June 2012 (UTC)

Cost
I really think the cost of this medication is worthy of a mention. I just checked with my insurance it costs $1,209.07 for 20 600mg pills. That is over $40/pill--K8TEK 13:43, 29 August 2006 (UTC)

re: Cost Yes, The cost is prohibitive. My insurance covered my prescription but 28 tablets was at $2000.00.re;cost

Cost is especially prohibitive if you are uninsured. Having to pay for a 30 day supply of Zyvox out of pocket cost me over $1500. --MathewBrooks 17:17, 20 August 2007 (UTC) I live in Australia and am on long term treatment wity Zyvox. I am a public patient and and pay absolutely nothing. There is much to be said about our just health care system. Adrian58.161.106.31 (talk) 00:46, 8 January 2008 (UTC)

Do you have a reference for Canadian pharmacy costs? It's still under patent in Canada, and public formularies (such as ODB) still pay $75 for. — Preceding unsigned comment added by 142.1.57.97 (talk) 23:45, 30 January 2013 (UTC)

extent and mechanism of resistance
Could anyone start a section on the extent and mechanism of resistance ? Rod57 (talk) 18:29, 5 January 2009 (UTC)
 * I've added a bit of information. Needs to be expanded to include worldwide data, mention of outbreaks and increasing endemic resistance in hospitals/ICUs etc. Fvasconcellos (t·c) 21:32, 17 January 2009 (UTC)

FA review

 * This review is transcluded from Featured_article_candidates/Linezolid/archive1.

U.S. sales in 2008
Nearly 250 million dollars in retail sales. Should work into the article somehow. Fvasconcellos (t·c) 02:41, 26 July 2009 (UTC)

S. pneumoniae
Staphylococcus pneumoniae is a classification mistake.streptococcos pneumoniae or diplococcus pneumoniae is the correct classification  —Preceding unsigned comment added by 89.97.126.1 (talk) 06:59, 14 September 2009 (UTC)
 * Corrected. Thank you so much for catching this. Best wishes, Fvasconcellos (t·c) 13:21, 14 September 2009 (UTC)

Note
It's been over a year since promotion, so I'm planning to do a broad update of the article using WP:MEDRS published since then. Not likely to change much, though. Fvasconcellos (t·c) 01:56, 18 October 2010 (UTC)

hypoglycemia
For possible use in article: http://cid.oxfordjournals.org/content/59/8/e93.full

Abstract Hypoglycemia was not previously known to be a linezolid-associated adverse reaction. A case report describing symptomatic hypoglycemia in a linezolid recipient prompted a review of the US Food and Drug Administration Adverse Event Reporting System, which demonstrated a relationship between linezolid and hypoglycemia. A warning with this information was added to the linezolid package insert.

50.0.205.237 (talk) 16:34, 27 September 2014 (UTC)

update?
televancin and dalbavancin are mentioned as "in development" on the page under "comparable antibiotics". televancin was approved in 2013 and dalbavancin was approved in 2014. I wonder how many other aspects of this article are out of date. — Preceding unsigned comment added by 198.49.6.225 (talk) 08:57, 30 May 2015 (UTC)
 * Excellent point. I have updated the article to reflect that. ― Bio chemistry 🙴 ❤   15:16, 29 December 2018 (UTC)

External links modified
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 * Added archive https://web.archive.org/web/20110723082633/http://www.elsevier.es/sites/default/files/elsevier/pdf/28/28v27n04a13136682pdf001.pdf to http://www.elsevier.es/sites/default/files/elsevier/pdf/28/28v27n04a13136682pdf001.pdf
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Interactions
The section on linezolid's DDIs with "serotonergics" leading to 5HT syndrome needs to be rewritten to reflect the nuances on this topic.― Bio chemistry 🙴 ❤   15:25, 29 December 2018 (UTC)


 * You have any reviews in mind that cover this?  Seppi  333  (Insert 2¢) 20:52, 30 December 2018 (UTC)
 * Here's a couple review articles that touch on the subject. I don't think that any of them truly do the topic justice, but it's a good starting point for discussion. Please see the below quotes from these articles (emphasis mine, in bold):
 * PMID: 20098528, "Given its status as a weak MAO inhibitor with powerful antibiotic efficacy, for which a special tyramine-depleted diet is not needed, linezolid's use with SSRIs should be dictated by informed clinical judgment. We propose that if a patient is taking an SSRI and requires linezolid for a new infection, the initiation of linezolid should not be delayed to washout the SSRI."
 * PMID: 23424229, "Although robust data are lacking and existing literature has limitations that cloud the true incidence, the reported incidence of serotonin toxicity with the use of linezolid is rare based on our review....Based on the small number of reported cases over the 12-year period that linezolid has been available and the low incidence in retrospective studies, we consider it to be reasonable to use linezolid in combination with a single serotonergic agent, such as an SSRI or SNRI, for severe or life-threatening infections when concomitant therapy cannot be discontinued."
 * ― Bio chemistry 🙴 ❤   05:22, 3 January 2019 (UTC)

History section
The last paragraph of the history section is out of date now. Tedizolid is approved (FDA, EMA) for clinical use, therefore Linezolid is no longer the only oxazolidinone available. Also, of the other listed agents in development, only radezolid appears to remain in some sort of active development (the other agents were abandoned). Baegun (talk) 10:30, 11 January 2022 (UTC)
 * But it says already that tedizolid was approved in 2014. Ruslik_ Zero 20:33, 11 January 2022 (UTC)