Talk:Loss of heterozygosity

Statement Needs Clarification
The statement in the introductory paragraph that "The majority of the genome within somatic cells of individuals are heterozygous" is confusing. Can someone please clarify?


 * That statement is confusing. I've rewritten it to hopefully be more clear; see what you think. --Mark viking (talk) 18:52, 2 September 2013 (UTC)

History of LOH
The article could use at least a brief history. When was LOH first identified? None of the references at the end are older than ten years -- surely people knew of LOH before 2004? — Preceding unsigned comment added by 128.250.5.254 (talk) 02:14, 18 June 2014 (UTC)

One more form of LOH not described
In copy-neutral LOH, there is one other way it can happen: a second mutation hit (normally at a different location) in the remaining good allele. I believe most researchers would refer to this as LOH, wouldn't they? Tedtoal (talk) 21:19, 15 September 2017 (UTC)