Talk:Metandienone

Mechanism of action
"Methandrostenolone does not react strongly with the androgen receptor, instead relying on activity not mediated by the receptor for its effects."

Results reported in: "Anabolic-androgenic steroid interaction with rat androgen receptor in vivo and in vitro: a comparative study" by B. I. Feldkoren and S. Andersson in J Steroid Biochem Mol Biol. (2005) volume 94 pages 481-487.  seem to suggest that even if methandrostenolone does not have a high affinity for the androgen receptor, it can still have effects of the androgen receptor. --JWSchmidt 14:00, 11 October 2005 (UTC)

You are correct, even though it has lower binding affinity for the androgen receptor, the reference says that it is still acting through the androgen receptor in vivo. This article is littered with pseduoscience and unsupported statements. --Settersr (talk) —Preceding undated comment was added at 19:44, 11 October 2008 (UTC).


 * Too right, it sucks. --90.240.69.136 (talk) 19:51, 11 October 2008 (UTC)
 * Reads like a dodgy advert to me. Testem (talk) 19:17, 15 March 2014 (UTC)

Metabolism
"The 17α-methylation of the steroid does allow it to pass through the liver without being broken down (hence causing the aforementioned damage to the liver) allowing it to be taken orally"

This sentence is mixing together two ideas. The structure of methandrostenolone makes it less rapidly converted to inactive forms than are some other androgens. However, this does not mean that it is not broken down by the liver. The sentence in the article implies that it it because methandrostenolone is not broken down by the liver that it damages the liver. This is very unlikely. Many of the key articles on this chemical were published in German. Maybe someone who can read German and who has access to a research library can sort this out.--JWSchmidt 21:47, 11 October 2005 (UTC)

Just curious, how has it been established 30mg per day is a "high dose"?

Answer: It doesn't sound high to me, but a check of an old PDR would determine the answer to your question. —Preceding unsigned comment added by Godofredo29 (talk • contribs) 19:04, 19 November 2007 (UTC)

Allusions to Sports Figures
The link to Bob Hoffman is not to the right Bob Hoffman. —Preceding unsigned comment added by Godofredo29 (talk • contribs) 19:01, 19 November 2007 (UTC)

The origin of methandrostenolone
Hi, I am confused by the information contained in the World Anabolic Review that methandrostenolone "was developed in the mid-forties and experimentally used on returning prisoners of war that had been on very low food intakes." Other sources say that it was synthesized as late as in mid 50's in USA. What is true? Centrum99 (talk) 21:56, 20 July 2008 (UTC)

Side effects and death due to liver dysfunction
Dianabol (methandrostenolone) is not directly responsible for that. Any medicine (steroidal or not) can cause death, because every medicine is hepatotoxic. Liver shut down appears only when using fancy dosages (in the case of Dianabol : over 50 mg a day) while not protecting the liver with Liv52 (for instance).

Professional (and amateur) bodybuilders do use it at 25-50 mg a day and do not suffer from liver dysfunction or disturbing side effects.

Maybe should it be useful to detail a bit more the cases when the use could lead to death. If it was so dangerous, no one would be taking steroids.

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First paragraph redundancy
In the first paragraph,it says that Dianabol is used for bulking cycles, and then it says that it's used non-medically. Even though dianabol is not used medically for bulking. It's essentially saying by omission that dianabol is used for medical bulking because the sentence right after describes the non-medical use. — Preceding unsigned comment added by 81.237.198.75 (talk) 10:48, 7 December 2021 (UTC)

Medical use?
"...is still quite often used because of its affordability and effectiveness for bulking cycles...It is also used non-medically" "Bulking cycle" definitely sounds like a non-medical use. Are there any medical uses at all now? 83.252.238.152 (talk) 10:29, 12 December 2021 (UTC)