Talk:Nephrotic syndrome

Comment
i am trying to make this a comprehensive text, please comment on the ease of readingHswapnil 21:50, 1 October 2005 (UTC)

Hi,

Thanks for the good work so far, but this article is not helpful to a layman due to the use of unfamiliar terms. I'm sure this is a continual problem for medical texts on Wikipedia; but some more simple explanations for any given technical term (where possible) would be very useful. My father is currently in hospital with an illness to which this article relates. However I am unable to understand enough of it for it to be useful to me.

Again, I thank you for the effort here; it's easy to be a critic and as such I wish to encourage you rather than dishearten you.

Take care,

GC. Gav (talk) 22:19, 13 December 2010 (UTC)

"Differential diagnosis" header
I understand how one might want to have accompanying descriptive text along with the disease listings, particularly since some of the diseases appear not to have accompanying Wiki articles, but please don't muck up the headers by demanding this kind of specific editing instruction on the header itself. Rather, make sure to include it as part of a neutral-toned text. I didn't include it as such because there are still lists of diseases prevalent in the applicable section and it would not be prudent to say "this section should include a descriptive look at diseases, not just a disease list," while it would be okay to say "this section includes...." So if someone with more information on this subject wants to edit in that kind of information plus text that would make it clear what would be most appreciated in terms of section content, that would be lovely. (Krushsister 19:19, 3 March 2007 (UTC))

Treatment
Under the heading treatment, there are many statements that would require at the very least a citation from an authoritative source. Without that or some statement to refer to your doctor, does it not open Wikipedia to potential liability? --HJKeats (talk) 14:03, 18 January 2008 (UTC)
 * This is covered by Wikipedia's general disclaimer. That said, if you're taking Wikipedia over the word of a physician you've probably got other problems.
 * In any case, the treatment section has to be trimmed down-- nephrotic syndrome is only a working diagnosis. Generally, it requires further work-up. If the person with nephrotic syndrome is a child minimal change disease is usually assumed and further work-up is dependent on responsiveness to treatment with steroids. Nephron  T|C 18:09, 21 March 2008 (UTC)

Reviews
209 review  Doc James  (talk · contribs · email) 22:26, 18 March 2011 (UTC)

Oncotic pressure
The article says that "Lower serum oncotic pressure causes fluid to accumulate in the interstitial tissues." This is a common misconception. The oncotic pressure is unchanged in nephrotic syndrome. The interstitial oedema is due to accumulation of sodium in the extracellular compartment. --129.240.158.84 (talk) 10:49, 19 June 2012 (UTC) Given that there is loss of protein and there may not be renal failure, do you have any source stating that there is accumulation of sodium and no change in oncotic pressure? 2.82.12.122 (talk) 10:02, 30 October 2012 (UTC)

I agree with the first comment... For instance it's also written in Harrison's Principles of Internal Medicine 18th ed in chapter Glomerular Diseases: Introduction -> Nephrotic Syndrome - "Edema secondary to salt and water retention can be controlled with the judicious use of diuretics, avoiding intravascular volume depletion." I also red in another literature (but not English) that proteins are being lost also from interstitial space and so osmotic gradient is not high enough to form edema. — Preceding unsigned comment added by 194.160.183.35 (talk) 18:50, 31 October 2013 (UTC)

Circular logic
The second paragraph says 'The cause is damage to the glomeruli, which can be the cause of the syndrome or caused by it'. This needs rewriting as it obviously doesn't make sense. — Preceding unsigned comment added by 86.29.15.158 (talk) 13:43, 18 October 2013 (UTC)

Corticosteroid tolerance or intolerance?
The section 'treatment of kidney damage' lists 'corticosteroid tolerant patient' as one type of responder to corticosteroid treatment. Below this it says 'Immunosupressors (cyclophosphamide): only indicated in recurring nephrotic syndrome in corticosteroid dependent or intolerant patients'. This looks like it might be a mistake. Should 'corticosteroid tolerant patient' actually be 'corticosteroid intolerant patient?' or is 'corticosteroid intolerant patient' another category of response that needs adding to the list? — Preceding unsigned comment added by 86.29.15.158 (talk) 13:48, 18 October 2013 (UTC)

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