Talk:Neuraminidase

Details on NA subtypes
Is there any more information on the different NA subtypes? (where they're found, what distinguishes one from another, how much variation there is for different strains within a subtype, etc.) -- 20:39, 27 August 2007 (UTC)

This article should probably be split up according to species. Currently the introduction/abstract refers only to mammalian NEU1, but other details refer to viral NEU. I would suggest this article discuss only the commonalities of neuraminidase catalysis and structure, followed by external references to the pages for viral NEU, NEU1, NEU2, NEU3, and NEU4. Since each of these enzymes has distinct functions (some clearly elucidated - and some not).--Glycoform (talk) 15:38, 3 January 2009 (UTC)
 * Done. --Arcadian (talk) 18:16, 3 January 2009 (UTC)

Incorrect information
The article says: "Neuraminidase also plays a role in the helping influenza pathogenesis by cleaving sialic acid from the host glycoprotein and allowing the virus to enter the host (T-phages, macrophages, etc.)"

But my Open University sk185 "molecules, medicines, drugs: a chemical story" disagrees. It says: "The specific role...seems to be to help newly formed viruses to escape from the host cell and spread to other cells in the body. They are then able to move on and infect other cells. As part of this process, sialidase [also known as Neuraminidase] cleaves off sialic acid groups...from the membranes of the host cells".

Which is correct? Does nueraminidase/sialidase help influenza enter or leave the cell? 82.15.59.176 (talk) 17:06, 28 October 2008 (UTC)

The latter description is correct; or at least is the explanation generally used. This would be clearer with the addition of a scheme and references to reviews.--Glycoform (talk) 15:38, 3 January 2009 (UTC)

Pfam Box
As nueraminidase isn't a family of proteins, rather a grouping of protein with similar function, would any one mind if I remove the pfam box which can already found on the more relevant Viral neuraminidase page? I'm thinking the image should be left though as it's quite a nice illustration and not been used on many other pages =D Abergabe (talk) 12:21, 2 September 2010 (UTC)

Expression systems
I added this new article from PLoS One where suitable expression systems are described. It seems important to obtain enough pure neuraminidase for research purposes these days to find new anti-influenza drugs, diagnostics and vaccines. I added this paragraph under "structure" but if that seems inappropriate please add it to another section or delete it altogether.Osterluzei (talk) 06:06, 8 February 2011 (UTC)

Assessment comment
Substituted at 01:04, 30 April 2016 (UTC)

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