Talk:Oligodendrocyte progenitor cell

- JSFinch (talk) 23:39, 26 July 2015 (UTC)==NG2 not necessarily OPCs==

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Not enough evidence exists either way as to whether NG2 glia are purely OPCs, or whether they are a different subtype. Sources within the past few years (including Velez-fort (2011, Glia)). Nishiyama (2009, Nature Reviews: Neuroscience) states that it is "now widely accepted that polydendrocytes (their name for NG2 cells) are OPCs that generate oligodendrocytes in the developing and mature CNS and serve as the primary source of remyelinating cells in demyelinated lesions. However, recent reports on the lineage and electrophysiological properties of polydendrocytes have challenged the notion that they are committed progenitor cells of the oligodendrocyte lineage with the sole function of generating myelin-forming cells." They then go on to talk about the evidence that polydendrocytes can have oligodendroglial, astroglial, and neuronal fates, which distinguishes them from pure OPCs. I think the consensus is lacking to distinguish them too much at this point. My inclination is to have two separate pages that refer to each other, rather than one that gives the impression that they're purely OPCs. Davemcarlson (talk) 03:18, 18 April 2013 (UTC)
 * Nishiyama in a 2009 Nature Reviews: Neuroscience paper noted that "OPC is a committed cell that generates oligodendrocytes. The terms 'NG2 cell' and 'OPC' are often used synonymously. In this article, the term OPC is used for cells whose identity as NG2-espressing cells was not examined." indicating that they were not entirely comfortable mixing the two. I think as long as a clear distinction is made, a merger is OK, but I think treating them as the exact same is questionable. Davemcarlson (talk) 03:24, 18 April 2013 (UTC)

Merger
I disagree. Several sources consider them a distinct cell type - a fourth type of glial cell in the CNS. These include Velez-Fort et al. (2011) and Butt (2002). Nishiyama wrote a review paper in 2009 stating that NG2+ cells should be considered "polydendrocytes", a type of possibly multipotent cells. Also, in 2002, Nishiyama stated that NG2+ cells are distinct from other cell types, stating that they are often oligodendrocyte progenitors in development, but they persist in the adult CNS; Nishiyama also considered them distinct from other cell types, a possible 4th glial population in the CNS. They also receive synaptic input from neurons in the CNS (Mangin 2011). Richardson (2011) (a review paper in Neuron) states that "a series of fate mapping studies [cast] NG2-glia as dedicated oligodendrocyte precursors in the healthy adult CNS - though rare, neuron production in the piriform cortex remains a possibility. following CNS damage, the repertoire of NG2-glia expands to include Schwann cells and possibly astrocytes - but so far not neurons."


 * Velez-fort, Audinat and Angulo (2009, Glia) state "Three main types of glia exist in the postnatal mammalian brain: astrocytes, oligodendrocytes, and microglia. During the last decade, however, another glial cell type, mainly identified by the expression of the chondroitin sulfate proteoglycan NG2 has emerged as a fourth major class of glia in the central nervous system (see Nishiyama, 2007 for a review)."


 * Therefore, I think it's helpful to keep them separate, although it would be good to flesh out the NG2 page more. Davemcarlson (talk) 03:04, 18 April 2013 (UTC)

I agree with most of what you have stated. I proposed the merger since all OPCs express the proteoglycan NG2 (and pdgfra for that matter), and in that way are NG2-glia (all the literature above). It seemed easier to propose a merger than to placing lots of similar information on both sites. As you said the terms 'NG2' and 'OPC' (and to a lesser extent 'polydendrocytes', or even 'synatocytes', or 'A2B5+ cells') are often used synonymously, leading to the fact that the term OPC is even used when referring to cells that can differentiate into astrocytes, thereby losing the original meaning of the name.

Taken together, I would propose to either leave the sites separate, but with extensive cross-references to one another and indeed toughen up the NG2 site, or to merge the two sites to a site called 'NG2-glia', which then would have a subsection for oligodendrocyte-lineage restricted OPCs. Either way, by toughening up the site(s) with referenced statements the degree of overlap between OPCs and NG2-glia should become clearer to any reader. 80.61.37.160 (talk) 04:22, 18 April 2013 (UTC)JS

I suggest that we make the NG2 cell article a subsection of this one. I took Nishiyama (2009)'s comment: "It is now widely accepted that polydendrocytes are oligodendrocyte progenitor cells (OPCs) that generate oligodendrocytes in the developing and mature CNS and serve as the primary source of remyelinating cells in demyelinated lesions" to be a compelling reason for doing so. If NG2 cells are indeed a subtype of OPCs, I argue that the information on the NG2 cell page belongs on this one.Rob Hurt (talk) 05:01, 8 September 2013 (UTC)

Proposed merge with Polydendrocytes
Page name is an aka of proposed target. Page name gets no hits on Google and does not register on ngrams. All the refs bar one on the page use the name oligodendrocyte progenitors or its other aka N2glia. Seems that it was proposed on talk page in 2016 but merge tags not added to pages. Iztwoz (talk) 15:34, 21 March 2019 (UTC)

Article section completely empty
Why is the "Adult myelination" section of this page completely empty? CoolGuy917 (talk) 11:11, 26 October 2023 (UTC)