Talk:Peptide YY

Article about PYY3-36, not about 'pure' PYY
This article is mostly based on a paragraph in a Nature reference about PYY3-36. PYY3-36 (the amino-terminally truncated form of PYY) has high affinity for the Y2-receptor and thus exerts an hypophagic (less appetite) effect. Normal PYY however works like NPY and has a very potent! hyperphagic (more appetite) effect! Please note that most PYY in humans is indeed in the PYY3-36 form, thus many people may use PYY when they refer to PYY3-36. However, it is possible to look at the effects of pure PYY by artificially injecting it in mice or rats. As described in the following references, this has indeed a strong hyperphagic effect.

Hagan, Mary M. (2002). Peptide YY: a key mediator of orexigenic behavior. Peptides, 23(2), 377–382. Hagan, M M, & Moss, D. E. (1995). Effect of peptide YY (PYY) on food-associated conflict Physiology & behavior, 58(4), 731–735. — Preceding unsigned comment added by 143.121.194.70 (talk) 15:29, 28 September 2011 (UTC)

There was a "Brief Communications Arising" in nature that PYY might not work. http://www.nature.com/nature/journal/v430/n6996/abs/nature02665.html Does anyone know the result of the discussion? —Preceding unsigned comment added by 84.61.43.61 (talk) 23:53, 27 January 2008 (UTC)

Is PYY the name of a gene or a protein? The article isn't clear on that. --Laklare (talk) 08:06, 24 February 2008 (UTC)
 * It looks as though the article has been clarified in the intervening years, but since the question is still here, PYY (all capital) is the name of the human gene. The mouse version of the same gene is written Pyy. Peptide YY is the name of the peptide, i.e. a short sequence of amino acids, part of a protein.  --Dan Wylie-Sears 2 (talk) 03:56, 3 May 2016 (UTC)

Confusion
This article seems a little confused — it describes a protein in mice and humans in the infobox, but the link appears to be to porcine PYY; it seems utterly unnecessary to me to make more than a remark of the fact that the name is used, loosely, for the gene sequence as well as the resulting protein. The claims made as facts in the article seem, to put it mildly, quite strong, particularly the one about aluminium.

How long a peptide is this? I'm not sure whether daltonage or amino acid count is the standard, but neither appears to have been put into the article. From the description, it seems that this protein is released into extracellular space when synthesised.

Maybe it would be a good idea to be proactive and treat this substance/family of substances as a drug?

RandomP (talk) 18:57, 25 August 2008 (UTC)


 * my apologies, the length is stated in the article. RandomP (talk) 19:01, 25 August 2008 (UTC)

Reference 7 does NOT support the notion that you can ingest PYY in a usable form from eating Atlantic Salmon. This sentence is very misleading. — Preceding unsigned comment added by 70.105.16.96 (talk) 02:10, 24 March 2022 (UTC)