Talk:Platelet

Latest Discovery
Most of the body's platelets are generated in the LUNGS! http://www.sci-news.com/biology/lungs-blood-production-04734.html. Somebody please clean up my blurb in the history section. I know I did it badly. 152.132.1.16 (talk) 18:51, 27 March 2017 (UTC)

Untitled
To the anonymous user rewriting a lot of this article. It looks like good stuff, but can you let me know your sources? Zeimusu 13:48, 2004 Nov 3 (UTC)


 * Most of this is stuff found in any medical textbook. I don't think there is an immediate need for resources on the material added. JFW | T@lk  16:43, 3 Nov 2004 (UTC)


 * Ok, I'm fine with that.Zeimusu

Platelet
Whats a platelet? —Preceding unsigned comment added by De Mattia (talk • contribs) 06:26, 6 August 2008 (UTC)


 * Thanks for the question. A platelet is a very, very small plate, typically 4-7mm in diameter, usually with a distinctive rim called a thrombrim.  It was a popular member of household table china collections in the period of 1736-1742, when a particular style of dessert-dining was in vogue, called "peu gormand."  Peu gormand were small desserts, typically a sweet dough that was soaked in rum and doused with syrup.  Peu gormand parties were popular all over Europe, but were particularly popular in Strassbourg and neighbouring regions during this time, and, along with copious quantities of red wine, party-goers would consume as many as 150-400 peu gormand in one sitting!  At one time, the peu gormand craze was so prevalent that it was estimated that 1X1011 platelets were being produced in Europe in one single day!


 * Many potters began to solely produce only platelets in response to the great demand, and were called Marrowers, after a fashionable London socialite named Emily Marrow, who, while very tipsy at a dinner party, untied her bodice, threw it upon the table, decried her host's platelets as being substandard, and declared that she would only buy her platelets from potters who made nothing else! What wonderful drama!


 * Marrowers were able to profit greatly, and because so many platelets were required for a single household, it became fashionable to produce themed sets of platelets. Popular themes were farmyard montages, political caricatures, and - although only available through the table china blackmarket - young lasses in various states of undress.


 * Of course, such bulging aneurysms of fashion are prone to haemorrhage suddenly and violently, and as tastes in dinner-parties changed, platelets dwindled to a passing memory. These days, what few platelets that remain are well-sequestered in the collections of a few ceramic-aficionados, and a full set of platelets is worth a pretty penny at reputable antique dealers.


 * Hope that answered your question! Electrosaurus (talk) 04:56, 6 October 2008 (UTC)

Sympotoms Of Thromcytopenia
Does anyone know what the symptoms of having a high platelet count over 1 million? Mdougherty79@msn.com


 * Thrombosis, paradoxical bleeding, erythromyalgia. JFW | T@lk  21:26, 1 April 2006 (UTC)

History
I found a useful historical resource about the discovery of platelets and their function here. JFW | T@lk  21:26, 1 April 2006 (UTC)

Richard Hill Norris
I have only found one source that links Prof Richard Hill Norris to the function of platelets. In contrast, Prof Douglas Brewer (himself a Birmingham emeritus) attributes the findings to Bizzozero, as I have now indicated in the article.

I have emailed Prof Brewer to see whether he knows more about R.H. Norris. For the moment, I think it is safer to attribute the discovery to Schultze and Bizzozero as per Brewer's historical article. JFW | T@lk  22:35, 11 April 2006 (UTC)

i think that uneed less big words and make it simple


 * Prof Brewer kindly replied to my email. Firstly, there was no University of Birmingham yet in 1878. Secondly, while Norris published on haematomorphology he did not primarily discover platelet function. I regard the matter as settled. JFW | T@lk  15:46, 16 April 2006 (UTC)

Anucleate
Do platelets in nonmammalian vertebrates have a nucleus? It would be nice if this were clarified in the article. --Aranae 03:09, 18 May 2006 (UTC)

What images should be used?
Suggest that the page has a picture of platelets on a blood film, perhaps a EM of a platelet as well, perhaps an image of a megakaryocyte at well. This is to replace the picture of the bag of plateletes, which is also on the platelet transfusion page. Snowman 14:26, 17 July 2006 (UTC)

History of platelets
http://www.ucl.ac.uk/histmed/PDFS/Publications/Witness/wit23.pdf - recent history of platelets in thrombosis and other disorders. Enormous document (>200 pages) on the history of platelets. Have no time to read it yet. JFW | T@lk  23:56, 23 April 2007 (UTC)


 * - the effects of ADP on platelets have been known since 1961! JFW | T@lk  16:57, 24 December 2007 (UTC)

Production
There isn't any information on where or how platelets are produced and introduced to the blood stream, or any methods one can take to increase or decrease the count naturally. —Preceding unsigned comment added by 213.202.139.92 (talk • contribs)


 * It says quite clearly that platelets are made in the bone marrow. There are no specific "natural" (what do you mean?) methods of manipulating the platelet count. JFW | T@lk  14:34, 7 April 2008 (UTC)

Transfusion Medicine
Added information on volume reduction of platelets for pediatric use. Garffreak (talk) 01:18, 1 February 2008 (UTC)

Platelet LOW LEVELS
This question has been removed. Per the reference desk guidelines, the Wikipedia is not an appropriate place to request medical, legal or other professional advice, including any kind of medical diagnosis or prognosis, or treatment recommendations. For such advice, please see a qualified professional. Hroðulf (or Hrothulf) (Talk) 22:24, 16 October 2008 (UTC)--Hroðulf (or Hrothulf) (Talk) 22:24, 16 October 2008 (UTC)

Size?
I see all sorts of information, but one surprising omission -- what size are these things? Paul Koning (talk) 11:52, 26 February 2009 (UTC)

repetition of information in opening paragraph
"Platelets, or thrombocytes, are small, irregularly shaped anuclear cells" "Like red blood cells, platelets have no nucleus." looks like someone added the second one in separately, but do both statements really need to be there? Joel.labes (talk) 07:18, 25 March 2009 (UTC)

Thrombocytosis
I have been taught the upper limit of normal for platelet count is 400 x 109 / L not 450 x 109 / L, indeed by Oxford Handbook of Clinical Medicine (cheese & onion) and Clinical Medicine by Kumar & Clark back this up. However Lab Tests Online claims it to be 450. Anyway, this has been changed to 400 with Kumar & Clark as the more reliable reference. |→ Spaully₪† 23:54, 26 March 2009 (GMT)


 * I'm a chronic ITP patient who has engaged in extensive research on thrombocytopenia and the treatments available. I am currently enrolled in the Amgen NEXUS program and am receiving Nplate (to which I'm responding, BTW).  Both my hematologist and Amgen personnel with whom I've been in contact state that the "normal" range for most healthy adults is 150x109–450x109.  I had mentioned the Kumar & Clark data to the hematologist (who is also an assistant professor of medicine at a well known U.S. university) and he said the 400x109 number is now considered too low, at least in the USA.  I don't know if the criteria are different in the UK. |→ Bigdumbdinosaur (talk) 01:20, 4 April 2009 (UTC)


 * That's interesting to hear, as I've said I still am taught 400 but I will ask a haematologist here about it when I come across one. I have looked for recent papers on this but was unable to find anything definitive, I think I will leave it with the Kumar & Clark figure until I find something more recent and reliable.  Do change it if you have a better reference, I imagine you know significantly more than me on the matter.  Interesting to read about romiplostim, I'd not heard about that before, hope it continues to work! |→ Spaully₪† 11:40, 4 April 2009 (GMT)


 * I forgot to mention that, as an Nplate (romiplostim) patient, I am required to undergo a weekly CBC. The printed report from the lab states that the normal range for platelets is 150,000-450,000.  If I had a way to do it, I'd put up a scan of the report for your reference.  Maybe American blood is thinner than British blood&mdash;or is it the other way around?  


 * BTW, romiplostim is fresh off the block. The FDA approved it in August for limited field use&mdash;I am one of the first chronic ITP patients to get it following the FDA approval.  There are still a number of unknowns with the drug, one being what the long-term effects of continued usage will be.  Bone marrow fibrosis is a potential problem, as is hepatotoxicity (the latter definitely a problem with eltrombopag, an oral analog to romiplostim).  The fibrosis issue could be deadly, as it may cause extremely severe anemia.  For me, at least, the potential risks are secondary to the problem of a platelet count crash and a major bleeding event.  I hate it when blood starts leaking out of everywhere.  It makes me look like a worn-out automatic transmission. |→ Bigdumbdinosaur (talk) 02:46, 6 April 2009 (UTC)

Cell?
Ok, my bio book explicitly states that platelets are not cells (Biology/Biología, by Solomon, Berg and Martin), but part of cells, from megakaryocytes. It goes on saying that blood is composed of plasma, which contains proteins and else (nutrients and else, you get it), along with "cells and platelets", clearly making a distinction between the too. I know platelets not being cells is debatable, so, what is the consensus? 205.211.221.52 (talk) 06:30, 19 May 2009 (UTC)


 * It depends on your definition of a cell - if you take the dictionary definition of "The smallest structural unit of an organism that is capable of independent functioning, consisting of one or more nuclei, cytoplasm, and various organelles, all surrounded by a semipermeable cell membrane." - then platelets are clearly not cells, because for one, they are anuclear. Kavanagh21 (talk) 09:01, 23 October 2009 (UTC)

Other functions
- what platelets do when they're not participating in haemostasis. JFW | T@lk  10:44, 22 October 2009 (UTC)

Platelet image
The main image in the header of the article shows two platelets in a smear of blood cells. These cells are referred to in the image information as Giant Platelets (they are pretty big for 'normal' platelets). Would it be better to get an image of regular platelets under high mag.? If so, I will take some and post them up. Kavanagh21 (talk) 09:01, 23 October 2009 (UTC)


 * The original File:Giant platelets.JPG file, I don't believe magnification is 40X. Maybe the objective is 40X? Ward20 (talk) 21:37, 22 January 2010 (UTC)

Can we have a section on structure
A new section, near the top, could explain their structure - eg no nucleus, what type of surrounding membrane, what surface receptors, what internal structures ? do they contain DNA and ribosomes ? Rod57 (talk) 11:45, 30 April 2010 (UTC)

Article is wrong about the effect of transfusion
A quote from the article: "Low platelet counts are, in general, not corrected by transfusion unless the patient is bleeding or the count has fallen below 5 x 109/L."

I just had transfusion when my count was 32. The platelet level rose to 157. I wasn't bleeding. If the count is not corrected, in general, by transfusion, my doctor wouldn't have done it. Myez (talk) 04:58, 18 November 2010 (UTC)

Populations and functions
10.1111/jth.12045 reviews the possibility that there might be multiple populations of platelets with different cell surface receptors engaging in fibrin stabilisation and clot retraction respectively. JFW &#124; T@lk  17:07, 30 January 2013 (UTC)

Production from stem cells
10.1111/bjh.12764 JFW &#124; T@lk  20:46, 17 February 2014 (UTC)

Br J Haem!!
An entire issue with reviews about platelets: 10.1111/bjh.2014.165.issue-2. Great for this article or indeed any related article. JFW &#124; T@lk  20:54, 2 April 2014 (UTC)

Choice and location of pictures
The picture showing the internal structure of the platelet is in no way related to the subject matter it is next to - and is EXCELLENT. I would like to see it at the top.

On the other hand, the current picture at the top - the normal blood smear - only has ONE platelet on it, with no arrow pointing it out: useless. Needs replacing.

Also, the pictures of the bag of clumped platelets and bag of platelet concentrate, and the smear of clumped platelets, serve no purpose, in my view. Recommend delete. — Preceding unsigned comment added by IiKkEe (talk • contribs) 19:29, 11 April 2014 (UTC) IiKkEe (talk) 05:00, 16 April 2014 (UTC)
 * I have replaced the top picture with one of mine that shows the typical appearance of platelets in a stained blood film (smear). I agree that the unit of platelet concentrate serves little purpose (it looks the same as a unit of fresh frozen plasma). I would keep the picture of the stained film of clumped platelets; hematologists have to know what these look like as automated full blood count instruments can give falsely low platelet counts when clumps are present in the blood sample. The test tube of aggregated platelets serves little purpose. With regard to moving my diagram of the structure of a platelet see WP:BOLD. :-) Graham Colm (talk) 21:02, 16 April 2014 (UTC)

Megakaryocyte reference
I have a reference for the word megakaryocyte in the first paragraph, but I don't know how import a reference. Anyone care to help? It's Blood Cells 1989; 15(1): 23-47 Stenberg PE, Levin J: Mechanisms of platelet production. — Preceding unsigned comment added by IiKkEe (talk • contribs) 18:24, 17 April 2014 (UTC)


 * Paste this in the article (from the edit screen):. Graham Colm (talk) 18:58, 17 April 2014 (UTC)

Platelets Third Edition by Michelson
The 1327 page 2013 Third edition of Michelson's "Platelets" has a good chunk of each chapter available free online, called a preview; full access to table of contents and all 40,000 references at sciencedirect.com/science/book/9780

IiKkEe (talk) 02:14, 18 April 2014 (UTC)

Platelet transfususions
I think we should consider Platelet transfusions having its own page, and this page should have just a 3 sentence summary of the principles. I have not written or proofed this section, and I'm not qualified to monitor it.

There are seven references for this section: all current, that's good - but 27 unreferenced sentences that need to be verified and cited if necessary. Any thoughts about who could review and monitor this section? (I have reorganized the heading and added subsections.)

IiKkEe (talk) 02:13, 25 April 2014 (UTC)


 * We already have an article on plateletpheresis but for some reason it's not linked from here. I agree that the current section here is too long and detailed and is also poorly sourced for medical content as some completely lacks citations and other parts are sourced to primary research e.g. this. It should be mentioned here, with a link pointing readers to the main article. SmartSE (talk) 21:12, 25 April 2014 (UTC)

Inadvertent misrepresentation of edits as "minor"
I have completed 540 edits since Apr 11, and marked 508 of them as minor, out of ignorance as to the difference between a minor and major edit. In fact, probably 90% of these edits were not minor, but major. I have been told it is not possible to go back and correct this; and that the purpose of this label is so minor edits can be deleted from any count or audit. My edits will be properly labeled in the future, and I welcome an audit of any and all of my edits for appropriateness.

IiKkEe (talk) 05:41, 29 April 2014 (UTC)

Lead first paragraph
For any looking for information on how I am using the term platelet and thrombocyte on this page, and which is found in which animals, here is a quote from Levin, page 3, Chapter 1 "The Evolution of Mammalian Platelets" in Platelets. 3d edition 2013, By Michelson: "Polyploid megakaryocytes and their progeny, nonnucleated platelets, are found only in mammals. In all other animal species, cells involved in hemostasis and blood coagulation are nucleated. The nucleated cells primarily involved in nonmammalian, vertebrate hemostasis are designated thrombocytes to distinguish them from nonnucleated platelets. The presence of nonnucleated platelets and their polyploid megakaryocyte progenitors only in the bone marrow and/or spleen of mammals suggests that some important feature of mammalian physiology benefits from this unique mechanism for the production of anucleate cells from the cytoplasm of a larger cell, for the apparently major purpose of supporting hemostasis...

IiKkEe (talk) 07:10, 8 May 2014 (UTC)

--- Thanks for the clarification. If I understand you correctly, "thrombocytes" are commonly found in vertebrates, but non-nucleated thrombocytes, or "platelets" are unique to mammals. This is an interesting point which deserves clarification. Note however, that "thrombocyte" redirects to this page, and the article does not yet make any distinction between the terms thrombocyte and platelet. The textbook you cite makes an appropriate distinction between the two, but in everyday parlance, I'm not sure biologists stick this with convention. For example, a search of PubMed turns up a number of developmental biology articles which refer to platelets in Xenopus laevis (lab frogs). They probably should refer to thrombocytes. To further confuse matters, frogs have PDGF (platelet derived growth factor) in their serum.

Perhaps the following intro would provide better clarity to these points: Thrombocytes are cellular elements, found in the blood of vertebrates, that are important for the initiation of blood clotting.[1] In mammals, thrombocytes consist of blood platelets, which are 2-3 µm cytoplasmic fragments of bone marrow megakaryocytes which bud off into the circulation.[2]  In non-mammalilan vertebrates, thrombocytes circulate in the blood as nucleated cells, and are a similar size to erythrocytes.

I must confess, I also do not understand the description of platelets as a "biconvex disc". This seems like a term invented to contrast them from the better known "biconcave disc" shape of erythrocytes. There are plenty of photographs of platelets, either Wright Giemsa stained, or electron micrographs, on the web and in histology atlases. I've never seen anything that resemble a biconvex lens of eyeglasses. In reality they are sort of irregular spheroids with lots of finger like projections. mattelfesso (talk) 08:19, 10 May 2014 (UTC)


 * I agree with all the points and observations made by Mattelfesso. The alternative lead sentence offered is an improvement on the current version and the description of platelets as a "biconvex disc" is new to me and not true. Graham Colm (talk) 09:55, 10 May 2014 (UTC)

Mfero - first, thanks for calling my commentary insightful. Second, thanks for being willing to discuss first, rather than editing first. The WP "BRD" guideline for discussing differences would in my view be better served by a "DP-DO-AA" guideline: Discuss privately [on the home page of the first author (in this case, that's me)]; then the first two (that's us) discuss publicly (on the talk page here) any unresolved issues for the public to weigh in on; then if the two initial discussants still cannot agree, have an Administrator arbitrate. While all this is going on, no editing or reverting on the site. Since that is exactly the way we started, I'm hoping we can continue with that approach.

I'd like to discuss "biconvex discs" first and "platelets vs thrombocytes" later. First: have you read my "Morphology change" subsection under "Platelet dynamics"? If not, I hope you will, and let me know if there's anything there that you disagree with: it's all related to this discussion. Second, do you have access to Michelson's book, Platelets? That will let me know whether to refer to it by page, or paste quotes from it here as needed.

I'll start with a link, not to try to prove a point, just to see where we can find a point of agreement. This is a scanning electron micrograph of the structure of the the platelet in various stages of activation. What is your impression of the morphology of the unactivated platelet depicted on the left? It looks a bit like a breakfast sausage or a pancake to me! []

OK - your question has already caused me to decide to change my wording: several authors describing platelets say "discoid" not disc, so I'm changing that right now.

Another photograph of a discoid biconcave platelet showing the thin edges and "fat" center is on p 118 of Michelson - sorry no way to transmit it to you, and it's not online. Spending $205 or going to a medical library would be your only way to access it. I'll stop here and wait for your response.

Regards -

IiKkEe (talk) 15:32, 10 May 2014 (UTC)


 * Thanks for comments everyone. A couple of questions were raised, so I'll try to give a bit more input.

mattelfesso (talk) 13:55, 14 May 2014 (UTC)
 * Thanks IiKkEe, for the Talk guidelines. I appreciate reminders, since I inevitably get lost trying to find the style guidelines.  On another technical note, I notice that there are a large number of edits over a short time period (more than 80 edits from 5/11/2014-5/13/2014).  I'm wondering if its better for editors to try to batch changes (perhaps by section) rather than parse out each smaller change?   The reason I ask this, is that this makes it a lot harder to compare to my (or other peoples) prior edits.
 * Regarding platelet shape. I'm fine with the term "discoid". The link by IiKkEe to the JBC cover photo is helpful. (Too bad its copyrighted.)  I think the key word here is "inactivated" platelets, since there is a radical morphology change upon activation (not to mention clumping).  If I were to use a food analogy (which I don't recommend) I would probably call it a "bun".  :)  My main concern about Introductory paragraphs, in general, is that they are clear and to the point.  While a mention of the size and shape may be fine, it should not detract from the general message about what a platelet is, and what it does.  So its better to say a platelet has a discoid shape, rather than it is a disc (adjective vs. noun).  I note also that the historical information, later in the article, the histologists sort of varied on what to call them, (spherules, discs, plates, platelets).  Not knowing what they did, I imagine they focussed on their appearance and shape. Is it worth mentioning that the term "platelet" was originally coined in reference to their discoid shape?
 * One could argue for a couple of different approaches to the question of distinguishing "thrombocytes" from "platelets". I'm hesitant to focus too much on semantics, except when it improves the clarity of the article. From a biological perspective, my inclination is to speak in general terms (all vertebrates), and then become more specific (mammals/humans).  I realize though that most readers will be primarily interested in human platelets, and then, secondarily, on how this contrast this on how it is in other animals.  This is also how things were worked out historically by scientists.   Still an understanding of the developmental relationship of thrombocytes to erythrocytes (having a common cellular progenitor) and the evolutionary relationship of megakaryocytes/platelets to nucleated thrombocytes of vertebrates provides some clarity in an otherwise bewildering array of cell types and terminologies.

Delete section until complete
I have deleted this section pending its completion and will "park" it here.

Ultrastructure and function

 * Mitochondria
 * Surface glycoproteins
 * Dense tubular system
 * Microtubular system
 * Open canalicular system
 * Plasma membrane
 * Cytoskeleton
 * Alpha granules
 * Dense granules
 * Glycogen granules

IiKkEe (talk) 04:11, 13 May 2014 (UTC)

Sources for uraemic platelet syndrome
I removed:


 * Uremia, a consequence of renal failure, leads to platelet dysfunction that may be ameliorated by the administration of desmopressin.

This was out of place in the section about drugs causing platelet dysfunction. I couldn't readily find another section on diseases that affect platelet function, but this is great source: (remove the Medscape URL if copying this to the main article). JFW &#124; T@lk  19:17, 16 September 2014 (UTC)

Role in other pathologies
Review in JTH: 10.1111/jth.12730 (platelets in infection and inflammation). JFW &#124; T@lk  19:19, 16 September 2014 (UTC)

Assessment of IPFD
Inherited platelet function defects are rare, but this ISTH guideline discusses how they should be assessed 10.1111/jth.12792 JFW &#124; T@lk  17:38, 19 November 2014 (UTC)

Why does "thromboplastid" redirect here?
Not defined or mentioned in article. 109.157.79.50 (talk) 07:19, 9 January 2015 (UTC)

Because it's a word that means "platelet". Lboukoko (talk) 00:00, 12 April 2018 (UTC)

Assessment comment
Substituted at 03:07, 30 April 2016 (UTC)

Platelets
If platelets goes down it causes bleeding in human body. It can be decrease due to typhoid ( entric fever) or water and food. Sometimes down platelets is not harmful but you should take treatment when platelets goes down Rajababumy (talk) 01:02, 23 January 2018 (UTC)

Computation of platelet size?
The article mentioned as a reference for the claim "2–3 µm in greatest diameter" does not mention a diameter explicitly (or I was not able to find it). It states that the mean platelet volume is 6.6 fL, which corresponds a diameter of 2.3 \mu m. Therefore I removed the "greatest" in the above claim. Answer if you have an opposite opinion on the matter. Lboukoko (talk) 23:59, 11 April 2018 (UTC)
 * Lboukoko The unactivated platelet is not a sphere, it is a symmetrical biconvex disc; the "diameter", or distance between two comparable opposite points on its surface, is a function of the plane through which it is measured. This is not a precise use of the term diameter, but it is used here informally to get the message across. There is, in fact, a "least diameter" and a "greatest diameter" as well as many measurements between these two extremes. Thus, the statement "2-3 um in greatest diameter" is accurate, although it may not be supported by the cited reference.


 * Yes, the reference states that the mean platelet volume is 6.6 fL, but that corresponds to a mean diameter of 2.3 um/m, not the one diameter; there is no such thing.


 * The word "greatest" still appears in the article as it should, not removed as stated above, so this discussion is moot. IiKkEe (talk) 04:26, 18 June 2018 (UTC)

Relevance of "automated digital image analysis" mention?
Copy of [Relevance of "automated digital image analysis" mention?], a comment that applies to this article to: "On February 11th, user Johannes A. Schmidt added a mention of an article he seems to be an author of (as well as a freeware), and did a similar modification on the platelet article. The modification is [|here], and the quoted article is here.

I think that the comment is too precise to be relevant for the article, and would require user Johannes A. Schmidt to give more details about the relevance of this comment if he wishes to maintain it. I'll delete it if I get no comment."

Lboukoko (talk) 15:45, 23 May 2018 (UTC)

Deletion of the word "clot" created numerous errors
In the edit of 20:45 31 August 2018, the word "clot" was deleted throughout, leaving many sentences unintelligible, e.g. "contain clotting mediators" becomes "contain ting mediators". I tried to undo the edit, but subsequent edits blocked this. The page needs to be heavily edited. — Preceding unsigned comment added by Tamunro (talk • contribs) 15:04, 1 October 2018 (UTC)
 * Well spotted Tamunro. These errors were caused by you. Could you please fix them? Thanks SmartSE (talk) 15:42, 1 October 2018 (UTC)

No mention of platelet testing for CBC w DIFF blood testing
"PLT" is not found on this page. A subsection describing the inclusion of platelet count during a blood test would be useful, so that CBC / blood testing pages can link to it from their discussion of PLT levels. Darkskysunflowers (talk) 02:23, 18 November 2022 (UTC)
 * I agree the measurement section was poor, so I have changed it and added better references. Feel free to add/edit. I am not sure where/whether "PLT" fits within this, but there is now a reference to FBC/CBC now. |→ Spaully ~talk~ 09:54, 18 November 2022 (UTC)
 * Thank you for your added references! I've moved some things around and might stomp around with some major edits.  I would love to condense the header, and I've already tried to remove some of the verbosity from Platelet.  This article strikes me as information-full but lay-reader-opaque.  I'd like to preserve the relevant info while removing the dictional fluff.  Feel free please to revert any of my edits if they are inappropriate.  Best ~ Darkskysunflowers (talk) 19:01, 18 November 2022 (UTC)