Talk:RNA-dependent RNA polymerase

Wiki Education Foundation-supported course assignment
This article was the subject of a Wiki Education Foundation-supported course assignment, between 11 January 2021 and 21 April 2021. Further details are available on the course page. Student editor(s): Katie.toperzer.

Above undated message substituted from Template:Dashboard.wikiedu.org assignment by PrimeBOT (talk) 07:39, 17 January 2022 (UTC)

Moving VPg
I'm going to move the section on VPg to the Picornavirus article because it is too specific for this article. Xenobiologista (talk) 18:46, 17 February 2014 (UTC)

Relevant use for RNA-dependent RNA polymerase information
How can understanding the mechanism of RNA-dependent RNA polymerase lead to it's use in scientific technologies, such as RNAi, or drug therapies against viral pathogens? Katie.toperzer (talk) 19:56, 31 January 2021 (UTC)
 * They are used in RNA viruses. Past that, it is probably off-topic here. Note especially WP:NOTHOWTO. There should be genomics textbooks that well describe the process. Gah4 (talk) 23:25, 11 January 2022 (UTC)
 * They are used in RNA viruses. Past that, it is probably off-topic here. Note especially WP:NOTHOWTO. There should be genomics textbooks that well describe the process. Gah4 (talk) 23:25, 11 January 2022 (UTC)

Merge/Rename?
Would anyone mind if I renamed this article to RNA-dependent RNA polymerase and merged RNA replicase into it? Narayanese (talk) 13:02, 29 March 2008 (UTC)

Only negative-stranded RNA virus?
In the 2nd paragraph, it is written that "RNA-dependent RNA polymerase (RdRp) is an essential protein encoded in the genomes of all RNA-containing viruses with no DNA stage that have sense negative RNA", however, I can't understand what "that have sense negative RNA" means. Does it mean that RdRp is essential for all negative-stranded RNA virus? If so, I think we should remove this sentence because RdRp is essential for not only (-) RNA virus but also (+) and dsRNA virus, according to references. Thank you. Karasunoko (talk) 03:58, 11 September 2015 (UTC)
 * Well, we might link to Sense_(molecular_biology) which explains viral RNA. A positive strand (or sense) RNA, like mRNA, is ready to be translated by a ribosome into protein. In that case, the first protein should be some type of polymerase. A negative strand, also called negative sense, RNA virus needs to include an RdRp to make positive sense copies of itself. A positive sense RNA virus can make DNA or RNA copies of its genome. But yes I agree that the description is confusing, and probably could be improved. Gah4 (talk) 23:36, 11 January 2022 (UTC)
 * Well, we might link to Sense_(molecular_biology) which explains viral RNA. A positive strand (or sense) RNA, like mRNA, is ready to be translated by a ribosome into protein. In that case, the first protein should be some type of polymerase. A negative strand, also called negative sense, RNA virus needs to include an RdRp to make positive sense copies of itself. A positive sense RNA virus can make DNA or RNA copies of its genome. But yes I agree that the description is confusing, and probably could be improved. Gah4 (talk) 23:36, 11 January 2022 (UTC)

Plant RDR
And what about plant RNA-dependent RNA polymerases? — Preceding unsigned comment added by 195.113.47.253 (talk) 09:37, 4 December 2015 (UTC)

Assessment comment
Substituted at 03:46, 30 April 2016 (UTC)

an RNA molecule and a DNA one
a/an is based on the pronunciation of the next first letter

R = /ɑː/

proofreading
Some RNA viruses, such as corona viruses, do proofreading on their RNA polymerase. I don't know if it is part of the polymerase itself, or a separate protein. (Or separate subunit.) As the article indicates, the error rate of the usual RdRp is about 1 in 10,000, which is fine for smaller viruses, but too high for larger ones, like corona viruses. There is, then, now much interest in the workings of corona viruses such as Covid-19. This article could either mention it, or link to an article which does. Gah4 (talk) 23:40, 11 January 2022 (UTC)

Pronunciation of “RdRp”
How is “RdRp” pronounced?

One part of the article uses “a RdRp” which implies that it is pronounced with a starting consonant sound (“a redrip”, perhaps?) and not “ar dee ar pee” or “ar en ay-dependent…”. pne (talk) 05:46, 7 August 2022 (UTC)