Talk:Respiratory complex I

Not only mitochondrial
As mentioned in the section "Composition and structure" the NADH dehydrogenase is not only present in mitochondria, but also in some (or all?) bacteria, e.g. E. coli, M. tuberculosis. Therefore, the introduction as well as other sections (like "Function") should be improved.

Image is not a balanced equation
http://en.wikipedia.org/wiki/File:NAD%2BtoNADH.png The right hand side needs an extra proton (H+ ion). 143.167.172.113 (talk) 03:48, 28 February 2011 (UTC)

NAD+ to NADH Image Error
The picture in this page (http://en.wikipedia.org/wiki/File:NAD%2BtoNADH.png) is missing an N bond, right? — Preceding unsigned comment added by Homedog21 (talk • contribs) 18:46, 7 October 2012 (UTC)

Requested move

 * The following discussion is an archived discussion of a requested move. Please do not modify it. Subsequent comments should be made in a new section on the talk page. Editors desiring to contest the closing decision should consider a move review. No further edits should be made to this section. 

The result of the move request was: Not moved: A thorough policy-based reasoning for the move was not provided. — ΛΧΣ  21  03:15, 10 March 2013 (UTC)

NADH dehydrogenase (ubiquinone) → Respiratory complex I – ; NADH:ubiquinone reductase (H(+)-translocating) 193.60.81.245 (talk) 14:52, 25 February 2013 (UTC)

Survey

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Discussion

 * Any additional comments:


 * Could you elaborate on your reasoning for those of us who aren't molecular biologists? --BDD (talk) 18:12, 4 March 2013 (UTC)
 * The above discussion is preserved as an archive of a requested move. Please do not modify it. Subsequent comments should be made in a new section on this talk page or in a move review. No further edits should be made to this section.

NDUFA4 is not a subunit of complex I
There are two recent papers from two independent groups that demonstrate that NDUFA4 is not a subunit of complex I but a subunit of complex IV.

NDUFA4 is a subunit of complex IV of the mammalian electron transport chain. Balsa E, Marco R, Perales-Clemente E, Szklarczyk R, Calvo E, Landázuri MO, Enríquez JA. Cell Metab. 2012 Sep 5;16(3):378-86. doi: 10.1016/j.cmet.2012.07.015. Epub 2012 Aug 16. PMID: 22902835

NDUFA4 Mutations Underlie Dysfunction of a Cytochrome c Oxidase Subunit Linked to Human Neurological Disease. Pitceathly RD, Rahman S, Wedatilake Y, Polke JM, Cirak S, Foley AR, Sailer A, Hurles ME, Stalker J, Hargreaves I, Woodward CE, Sweeney MG, Muntoni F, Houlden H; UK10K Consortium, Taanman JW, Hanna MG. Cell Rep. 2013 Jun 27;3(6):1795-805. doi: 10.1016/j.celrep.2013.05.005. Epub 2013 Jun 6. PMID: 23746447 — Preceding unsigned comment added by 193.144.244.5 (talk) 07:16, 24 July 2013 (UTC)

NAD1?
Can someone tie in the "NAD1" terminology that is frequently used in molecular phylogenetics? At present this appears to be a gap in wikipedia. For example, "The nad1 gene encoding subunit I of the respiratory chain NADH dehydrogenase is fragmented into five unique-copy coding segments that are scattered over at least 40 kb and interspersed with other genes in the wheat mitochondrial genome." Sminthopsis84 (talk) 15:35, 13 January 2014 (UTC)

Merge with NADH dehydrogenase ?
I got to this page as well as the NADH dehydrogenase page from the electron transport chain page. The NADH dehydrogenase page looks more like a stub, and I'm not sure what the difference is between it and this page. (Is there an NADH dehydrogenase that doesn't use ubiquinol?).

Should the two be merged? I don't know how to start the process, or which talk page it should go on, so someone else can take this up now (or drop the whole thing). Jimw338 (talk) 04:39, 11 January 2015 (UTC)

Active/deactivated transition
This Active/deactivated transition section doesn't seem to have any references/citations. Richard8081 (talk) 20:49, 20 November 2015 (UTC)

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Complex i
"Complex i" redirects here. Should there be note and a link to the Imaginary unit as it may be the intended search? --Sw-f (talk) 12:14, 1 September 2021 (UTC)