Talk:Ryanodine receptor

Untitled
To write this, I will need to read JFW |  T@lk  14:24, 9 May 2005 (UTC)

Here's a good source: http://pharmrev.aspetjournals.org/cgi/content/full/49/1/1 KBi 04:53, 15 November 2005 (UTC)


 * Wouldn't you add the full academic references and cite the key points in the article? JFW | T@lk  07:51, 15 November 2005 (UTC)


 * You're evil! It's 51 pages long! JFW | T@lk  20:12, 15 November 2005 (UTC)

From signal transduction
This should be incorporated here:

The localized and time-limited activity of Ca 2+ in the cytosol is also called a Ca 2+ wave. The building of the wave is done by
 * The ryanodine receptor is named after the plant alkaloid ryanodine. It is similar to the InsP3 receptor and stimulated to transport Ca 2+ into the cytosol by recognizing Ca 2+ on its cytosolic side, thus establishing a feedback mechanism; a small amount of Ca 2+ in the cytosol near the receptor will cause it to release even more Ca 2+ . It is especially important in neurons and muscle cells. In heart and pancreas cells, another second messenger (cyclic ADP ribose) takes part in the receptor activation.


 * the feedback mechanism of the ryanodine receptor and
 * the activation of phospholipase C by Ca 2+, which leads to the production of inositol triphosphate, which in turn activates the InsP3 receptor.

JFW | T@lk  18:27, 9 May 2005 (UTC)

Im pretty sure that myasthenia gravis is a disease caused by antibodies against Ach receptors


 * Sure, but the 10% who are negative often have antibodies against other skeletal muscle proteins, such as MuSK and apparently also RyR1. JFW | T@lk  10:08, 26 March 2008 (UTC)

Why is there no article about the DHP receptor? 129.31.72.52 13:50, 20 May 2007 (UTC)


 * WP:BOLD, create it! Or rather, get a username and then create it. JFW | T@lk  10:08, 26 March 2008 (UTC)

Calcium-induced calcium release
Don't you think this process fundamental to cardiac physiology requires its own page (i.e. it doesn't redirect to this ryanodine receptor article)? Butterfly reflections 04:15, 27 May 2007 (UTC)


 * sofixit JFW | T@lk  10:08, 26 March 2008 (UTC)

Muscle fatigue
RYR1 apparently plays a significant role in muscle fatigue: JFW |  T@lk  10:08, 26 March 2008 (UTC)

Protein Interactions
I removed an existing (un-referenced) line about the "many" protein interactions involving RyR. Also cleanup up the section and added a reference. Would be nice to see more interactions listed (if, indeed, they do exist and can be properly cited!) Clayt85 (talk) 14:03, 22 May 2014 (UTC)

Wiki Education assignment: CHEM 378 - Biochemistry Lab - spring 2023
— Assignment last updated by Bubbstar (talk) 20:11, 15 May 2023 (UTC)