Talk:T helper 17 cell

Wiki Education Foundation-supported course assignment
This article is or was the subject of a Wiki Education Foundation-supported course assignment. Further details are available on the course page. Student editor(s): Immcarle7. Peer reviewers: Immcarl17.

Above undated message substituted from Template:Dashboard.wikiedu.org assignment by PrimeBOT (talk) 10:38, 17 January 2022 (UTC)

Existence of Th17 cells in humans
I removed the following from the article due the lack of sources;

"It must be noted that there is no direct evidence for the existence of this cell type in humans, although it seems that IL-17 can be produced by some T helper cells. It is also important to note that a major proportion of IL-17 found in humans is produced from an unknown source, macrophages/monocytes, neutrophils and other immune cells produce this proinflammatory cytokine as well."

Given that the first part of the statement calls into question the very existence of the article subject, a reference to the opinion of a noted academic is the minimum that should be provided here. I'm not sure what to make of the second part but it should be referenced and preferably be written so as to make it's relevence clear. DoktorDec (talk) 01:20, 16 December 2007 (UTC)


 * Not my editing, but I recall 'gitta Stockinger talking about it AAI a few years back. I'll see if I can patch in a review from her, or maybe Jay Kolls on the subject. Jbarin (talk) 21:43, 27 October 2010 (UTC)

I don't see the relevance of the paragraph below.

On Tuesday, July 19, 2011, a press release from the Yale University Office of Public Affairs and Communications (<>) stated that excess cells could be selectively redirected into the small intestine and controlled and eliminated there, providing immunological stability. — Preceding unsigned comment added by Sardine666 (talk • contribs) 11:01, 16 August 2011 (UTC) Sardine666 (talk) 11:03, 16 August 2011 (UTC)

Article update
Replaced some older primary sources by a more recent secondary source (2014 review), removed redundancies. Still too much primary literature as references Dr Olive (talk) 17:16, 10 June 2015 (UTC)
 * Adjusted to article 't helper cells' moving some content here. Dr Olive (talk) 11:21, 12 June 2015 (UTC)

Th17s in HIV and general reorganization
I want to add more content about Th17's and their role in HIV infection. They have been implicated in maintaining the intestinal epithelial barrier and preventing microbial translocation, a symptom of HIV progression. I also plan to write a short introductory paragraph to the Th17 page that references these HIV-related updates. Here are some sources that I am thinking of adding to the page:

Th17 in HIV
 * Bixler, S. L. & Mattapallil, J. J. Loss and dysregulation of Th17 cells during HIV infection. Clin. Dev. Immunol. 2013, 852418 (2013).
 * Hartigan-O'Connor, D. J., Hirao, L. A., McCune, J. M. & Dandekar, S. Th17 cells and regulatory T cells in elite control over HIV and SIV. Current Opinion in HIV and AIDS 6, 221–227 (2011).

Primary Papers:
 * Alvarez, Y. et al. Preferential HIV infection of CCR6+ Th17 cells is associated with higher levels of virus receptor expression and lack of CCR5 ligands. Journal of Virology 87, 10843–10854 (2013).
 * Falivene, J. et al. Th17 and Th17/Treg ratio at early HIV infection associate with protective HIV-specific CD8(+) T-cell responses and disease progression. Sci Rep 5, 11511 (2015).
 * Pallikkuth, S. et al. Maintenance of Intestinal Th17 Cells and Reduced Microbial Translocation in SIV-infected Rhesus Macaques Treated with Interleukin (IL)-21. PLoS Pathog 9, e1003471–16 (2013).