Talk:Transgenerational epigenetic inheritance

Untitled
I think this article is pretty sound in terms of the information provided. The additional links also help in providing context to the article in relation to additional information. Kswoolen (talk) 06:00, 29 January 2024 (UTC)

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WP:PHARM WP:MED and WP:NEURO ratings are based upon the associated article ratings in Talk:Addiction and clinical implications of.  Seppi  333  (Insert 2¢) 22:16, 16 August 2015 (UTC)

Ppentony (talk) 11:16, 15 March 2023 (UTC)==Unsigned section== I don't understand why the axin fused mice (kinked tail) are pictured when they are not referenced in the text. Also why isn't the work from Marcus Pembrey et al, included, surely that is one the best examples of transgenerational inheritance? And it is in humans. A good review can be seen here: http://www.nature.com/ejhg/journal/v14/n2/full/5201567a.html (assuming you have access to nature).

I agree that the inclusion of the mice should either be justified by quoting a source which claims that the trait can be inherited or removed. If it is just an example of how an epigenetic change in an individual can change that individual then it should appear in the main epigenetic article, not this one. Ppentony (talk) 11:16, 15 March 2023 (UTC)

Experts debunk study that found Holocaust trauma is inherited
The inherited trauma of Holocaust survivors study at the Icahn School of Medicine is apparently very likely to be worthless, see: http://www.chicagotribune.com/lifestyles/health/ct-holocaust-trauma-not-inherited-20170609-story.html The paragraph should probably be updated to strongly put the study into question. Roythebob (talk) 22:07, 23 September 2018 (UTC)
 * Given that it was a single study (primary research) which has been rebutted as unsafe, I've removed it. If it gets some support from further research and is then discussed as not necessarily worthless by a reliable secondary source (like a review paper in a major journal) then we can put something back, but for now, it's just bad science. It shows the good sense in WP:PRIMARY, by the way. Chiswick Chap (talk) 01:18, 24 September 2018 (UTC)
 * The National Library of Medicine and the American Journal of Psychiatry have published the paper, and it has since been cited by 72 articles as of September, 2020.
 * https://pubmed.ncbi.nlm.nih.gov/24832930/

Rwandan genocide
Should the study into the Rwandan genocide inhertiance be included?
 * https://www.usf.edu/news/2022/study-finds-rwandan-genocides-chemically-modified-the-dna-of-victims-and-victims-offspring.aspx
 * https://www.futuremedicine.com/doi/10.2217/epi-2021-0310 — Preceding unsigned comment added by 81.191.81.174 (talk) 18:48, 19 January 2022 (UTC)

Wiki Education assignment: Comparative Developmental Biology
— Assignment last updated by AccidentalHerpetologist (talk) 19:33, 20 February 2023 (UTC)

Failed verification
I can't find support for this claim "leading some to consider that due to epigenetics, modern biology should no longer reject the inheritance of acquired characteristics (Lamarckism) as strongly as it once did". The closest I can find in the referenced citation [here] is in the Conclusion where is discusses the Lamarckian nature of culture (as opposed to genes) and concludes: "In this and other respects, perhaps it is premature to compare humans to plants (as Burbank did) in terms of their capacity to recall past environments, in this generation and the next.", which seems nearly opposite to the claim made - at least in terms of humans. Tobus (talk) 00:37, 13 March 2023 (UTC)


 * Agree, since this hasn't been addressed I am going to remove that entire paragraph. Zenomonoz (talk) 11:23, 24 August 2023 (UTC)

In Humans
The "In Humans" section appears to be largely about intergenerational inheritence, not transgenerational. I've rewritten the introduction and removed most of the "Dutch famine" discussion - the ref profided explicitly says "The Dutch hunger winter [effect]... is not due to the transmission of epigenetic information through the maternal germline''" (emphasis mine). Reading the rest of the section it also largely seems to be discussion of intergenerational inheritance - where sperm, eggs or unborn babies are directly exposed to the negative environment, with no requirement (or proof) of any actual epigenetic inheritance. I don't really have time to rewrite it all right now (might get to it soon), and don't want to just blank the whole thing, so I've left it for now - if anyone wants to cast a critical eye over it, please do. Tobus (talk) 01:19, 13 March 2023 (UTC)


 * Thanks for your edits, yes this is controversial. I would appreciate any further edits you have. Perhaps including the fact that the "the Dutch hunger winter [effect]... is not due to the transmission of epigenetic information through the maternal germline" would actually be useful. Zenomonoz (talk) 11:22, 24 August 2023 (UTC)

Wiki Education assignment: Comparative Developmental Biology
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