Talk:Urate oxidase

Copper enzyme
The german Wiki entry holds that it is a copper enzyme, here it is stated that it does not contain a metal ion. Please resolve. —Preceding unsigned comment added by 82.82.184.151 (talk) 10:29, 25 November 2007 (UTC)
 * Per this page:
 * This enzyme was previously thought to be a copper protein, but it is now known that the enzymes from soy bean (Glycine max), the mould Aspergillus flavus and Bacillus subtilis contains no copper nor any other transition-metal ion.
 * Hope that helps! – ClockworkSoul 21:35, 20 March 2008 (UTC)

Relevance in humans
"It has also been proposed[who?] that the loss of this UO protein expression has been advantageous to hominids, since uric acid is a powerful antioxidant and scavenger of singlet oxygen and radicals. Its presence provides the body with protection from oxidative damage, thus prolonging life and decreasing age-specific cancer rates." How is that advantageous? —Preceding unsigned comment added by 142.167.120.225 (talk) 17:34, 20 July 2009 (UTC)
 * However, this is highly unlikely as proteins are capable of being activated only when concentrations exceed a certain amount. Huh? What is highly unlikely? Which proteins? Concentrations of what? This sentence doesn't make any sense. --Rhombus (talk) 13:01, 14 September 2013 (UTC)

5-hydroxyisourate mirror image
I believe that the 5-hydroxyisourate picture in the metabolic pathway at the beginning of the article (Uric acid to 5-hydroxyisourate to allantoin) should be mirrored. Both the uric acid and the allantoin are facing one way but the intermediate metabolite, the 5-hydroxyisourate is facing the other way.

I know there is not scientific relevance whatsoever in displaying the image one way or the other, but it but be much more intuitive and easier to follow/memorize this metabolic pathway if all the images share the most possible visual resemblance.

Diego — Preceding unsigned comment added by Diego Dabrio (talk • contribs) 07:42, 8 April 2013 (UTC)

Early primates?
This article says: "It was lost in early primate evolution,[3] and so is absent in humans and other higher apes." "Early" doesn't seem right. If it was absent in all simians (monkeys and apes) as well as tarsiers, but present in lemurs and lorises, then "early" would make sense. In this case, something like "recent" would be more accurate. Zyxwv99 (talk) 23:43, 6 May 2016 (UTC)