Taurochenodeoxycholate 6α-hydroxylase

Taurochenodeoxycholate 6alpha-hydroxylase (, CYP3A4, CYP4A21, taurochenodeoxycholate 6alpha-monooxygenase) is an enzyme with systematic name taurochenodeoxycholate,NADPH:oxygen oxidoreductase (6alpha-hydroxylating). This enzyme catalyses the following chemical reaction


 * (1) taurochenodeoxycholate + NADPH + H+ + O2 $$\rightleftharpoons$$ taurohyocholate + NADP+ + H2O
 * (2) lithocholate + NADPH + H+ + O2 $$\rightleftharpoons$$ hyodeoxycholate + NADP+ + H2O

Taurochenodeoxycholate 6α-hydroxylase is a heme-thiolate protein (P-450).