User:Joflaher

I am an academic M.D. Professor Emeritus with past training and certification in Internal Medicine and Hematology but have for the past 40 years focused on basic and clinical research in the following areas:


 * Chemotactic factors for human and non-human leukocytes.
 * Cellular arachidonic acid metabolism and its eicosanoid metabolites including 5-Hydroxyicosatetraenoic acid, 20-Hydroxyeicosatetraenoic acid, 15-Hydroxyicosatetraenoic acid, 12-hydroxyeicosatetraenoic acid, 5-oxo-eicosatetraenoic acid, 20-Hydroxyeicosatetraenoic acid, and the prostaglandins, leukotrienes, and lipoxins, as well as the metabolites of eicosapentanoic acid and Docosahexaenoic acid (also termed docosanoids) such as the various resolvins and maresins. While not directly working with them, I am editing the pages on the cytochrome P450 metabolites of arachidonic and other polyunsaturated fatty acids such as 20-Hydroxyeicosatetraenoic acid and the Epoxyeicosatrienoic acids.
 * Cellular linoleic acid and its metabolism and metabolites including 13-Hydroxyoctadecadienoic acid.
 * Other cellular Omega-3 fatty acid and Omega-6 fatty acid polyunsaturated fatty acids: their consumption, metabolism, and metabolites.
 * Cellular phospholipids and their metabolism and metabolites such as platelet-activating factor and diacylglycerols.
 * G protein coupled receptors for the agents cited above.
 * The enzymes (lipoxygenases, cyclooxygenases, epoxygenases, monooxygenases, and CYP450s) and metabolic pathways which produce or inactivate these various agents
 * The roles played by the above agents in human diseases including inflammation, allergy, and various human cancers such as those of the blood and lymphoid tissues, prostate, and breast.

I do not interact with pharmaceutical, medical, and other companies or groups that have drug and/or similar promotional interests.