1942 Xavier Musketeers football team

The 1942 Xavier Musketeers football team was an American football team that represented Xavier University as an independent during the 1942 college football season. In their eighth year under head coach Clem Crowe, the Musketeers compiled a 4–5 record.

Xavier was ranked at No. 127 (out of 590 college and military teams) in the final rankings under the Litkenhous Difference by Score System for 1942.