1945 Fort Pierce Amphibs football team

The 1945 Fort Pierce Amphibs football team represented the Fort Pierce Naval Amphibious Training Base, in Fort Pierce, Florida, during the 1945 college football season. Led by second-year head coach Hamp Pool, the Amphibs compiled a record of 4–9. The team's starting quarterback was Johnny Lujack.

The Fort Pierce Amphibs were ranked 40th among the nation's college and service teams in the final Litkenhous Ratings.