1977–78 Louisville Cardinals men's basketball team

The 1977–78 Louisville Cardinals men's basketball team represented the University of Louisville during the 1977–78 NCAA Division I men's basketball season, Louisville's 64th season of intercollegiate competition. The Cardinals competed in the Metro Conference and were coached by Denny Crum. The team played home games at Freedom Hall.

The team completed a 23–7 record and reached the Sweet Sixteen of the 1978 NCAA Tournament.

Schedule and results
!colspan=12 style=| Regular season

!colspan=12 style=| Metro Conference Tournament

!colspan=12 style=| NCAA Tournament