1980–81 Indiana Hoosiers men's basketball team

The 1980–81 Indiana Hoosiers men's basketball team represented Indiana University. Their head coach was Bobby Knight, who was in his 10th year. The team played its home games in Assembly Hall in Bloomington, Indiana, and was a member of the Big Ten Conference.

The Hoosiers finished the regular season with an overall record of 26–9 and a conference record of 14–4, finishing 1st in the Big Ten Conference. As Big Ten Conference Champions, IU was invited to participate in the 1981 NCAA Tournament as a 3-seed; the Hoosiers advanced to the championship game where Bobby Knight and the Hoosiers won their fourth national title.

Schedule/Results
!colspan=8 style=| Regular Season

!colspan=8 style=| NCAA Tournament

Awards and honors

 * Bob Knight, Big Ten Coach of the Year
 * Isiah Thomas, NCAA Men's MOP Award
 * Ray Tolbert, Big Ten Player of the Year