1980–81 Penn Quakers men's basketball team

The 1980–81 Penn Quakers men's basketball team represented the University of Pennsylvania during the 1980–81 NCAA Division I men's basketball season. The Quakers, coached by Bob Weinhauer, played in the Ivy League and had a 20-8 win–loss record.

Schedule
!colspan=9 style=| Ivy League tournament

!colspan=9 style=|National Invitation Tournament