2-methylcitrate dehydratase

The enzyme 2-methylcitrate dehydratase catalyzes the chemical reaction


 * (2S,3S)-2-hydroxybutane-1,2,3-tricarboxylate $$\rightleftharpoons$$ (Z)-but-2-ene-1,2,3-tricarboxylate + H2O

This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is (2S,3S)-2-hydroxybutane-1,2,3-tricarboxylate hydro-lyase [(Z)-but-2-ene-1,2,3-tricarboxylate-forming]. Other names in common use include 2-methylcitrate hydro-lyase, PrpD, and 2-hydroxybutane-1,2,3-tricarboxylate hydro-lyase. This enzyme participates in propanoate metabolism.

Structural studies
As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code.