2005–06 Midland Football Combination

The 2005–06 Midland Football Combination season was the 69th in the history of Midland Football Combination, a football competition in England.

Premier Division
The Premier Division featured 19 clubs which competed in the division last season, along with three new clubs:
 * Atherstone Town, promoted from Division One
 * Bridgnorth Town, relegated from the Midland Football Alliance
 * Cadbury Athletic, promoted from Division One

Also, Coventry Marconi changed name to Coventry Copsewood and Castle Vale KH changed name to Castle Vale.