2010 Regional League Division 2 North Eastern Region

2010 Regional League Division 2 North-East Region is the 2nd season of the League competition since its establishment in 2009. It is in the third tier of the Thai football league system.

The league was expanded from 12 clubs in 2009 to 16 clubs this season. The league winners and runners up qualiied for the 2010 Regional League Division 2 championship stage.

Renamed clubs
Mukdahan-Savannakhet renamed Mukdahan

Expansion clubs
Ubon Tiger, Nong Khai, Yasothon United, Nong Bua Lamphu and Kalasin joined the newly expanded league setup.

Serving bans
Ubon United are in the first year of their two-year ban.