2015 Mutua Madrid Open – Women's singles

Petra Kvitová defeated Svetlana Kuznetsova in the final, 6–1, 6–2 to win the women's singles tennis title at the 2015 Madrid Open. It was her second Madrid Open title.

Maria Sharapova was the defending champion, but lost to Kuznetsova in the semifinals.

Seeds
• 🇺🇸 Serena Williams (semifinals)

• 🇷🇴 Simona Halep (first round)

• 🇷🇺 Maria Sharapova (semifinals)

• 🇨🇿 Petra Kvitová (champion)

• Caroline Wozniacki (quarterfinals)

• 🇨🇦 Eugenie Bouchard (first round)

• 🇷🇸 Ana Ivanovic (third round)

• 🇷🇺 Ekaterina Makarova (first round)

• 🇵🇱 Agnieszka Radwańska (third round)

• 🇪🇸 Carla Suárez Navarro (quarterfinals)

• 🇩🇪 Andrea Petkovic (second round, withdrew)

• 🇩🇪 Angelique Kerber (first round)

• 🇨🇿 Lucie Šafářová (quarterfinals)

• 🇨🇿 Karolína Plíšková (second round)

• 🇮🇹 Sara Errani (second round)

• 🇺🇸 Venus Williams (first round)

Seeds
• # 🇰🇿 Yaroslava Shvedova (first round)

• # 🇺🇦 Lesia Tsurenko (first round)

• # 🇺🇸 Lauren Davis (qualifying competition)

• # 🇫🇷 Kristina Mladenovic (first round)

• # 🇷🇴 Monica Niculescu (qualifying competition)

• # 🇷🇸 Bojana Jovanovski (qualifying competition)

• # Mirjana Lučić-Baroni (qualified)

• # 🇺🇸 Christina McHale (qualified)

• # 🇩🇪 Julia Görges (qualified)

• # Polona Hercog (first round)

• # 🇷🇺 Elena Vesnina (first round)

• # 🇨🇿 Lucie Hradecká (withdrew, still competing in Prague)

• # 🇩🇪 Annika Beck (first round)

• # 🇳🇿 Marina Erakovic (qualified)

• # Ana Konjuh (first round)

• # Stefanie Vögele (qualifying competition)

• # 🇷🇴 Andreea Mitu (qualified)

Qualifiers
• # 🇩🇪 Julia Görges

• # 🇷🇴 Andreea Mitu

• # 🇪🇸 Paula Badosa Gibert

• # 🇧🇾 Olga Govortsova

• # 🇳🇿 Marina Erakovic

• # 🇨🇴 Mariana Duque Mariño

• # Mirjana Lučić-Baroni

• # 🇺🇸 Christina McHale