2018 Advantage Cars Prague Open – Women's singles

The women's singles of the 2018 Advantage Cars Prague Open tournament was played on clay in Prague, Czech Republic.

Markéta Vondroušová was the defending champion, but chose not to participate.

Richèl Hogenkamp won the title, defeating Martina Di Giuseppe in the final, 6–4, 6–2.

Seeds
• # 🇩🇪 Mona Barthel (quarterfinals)

• # Richèl Hogenkamp (champion)

• # 🇩🇪 Tamara Korpatsch (semifinals)

• # 🇨🇿 Tereza Smitková (first round)

• # Bibiane Schoofs (first round)

• # 🇮🇹 Jasmine Paolini (second round)

• # 🇨🇿 Barbora Krejčíková (second round)

• # 🇧🇬 Elitsa Kostova (quarterfinals)