2019–20 Southern Miss Lady Eagles basketball team

The 2019–20 Southern Miss Lady Eagles basketball team represented the University of Southern Mississippi during the 2019–20 NCAA Division I women's basketball season. The Lady Eagles, led by sixteenth year head coach Joye Lee-McNelis, played their home games at Reed Green Coliseum and were members of Conference USA.

They finished the season 15–15, 7–11 in C-USA play to finish in a tie for ninth place. They lost in the first round of the C-USA women's tournament to Marshall. The day following their loss, the rest of the games for the postseason tournament were cancelled due to COVID-19 concerns.

Schedule
!colspan=9 style=| Exhibition

!colspan=9 style=| Non-conference regular season

!colspan=9 style=| C-USA regular season

!colspan=9 style=| C-USA Tournament


 * Source: Southern Miss Athletics