2019 Internazionali di Tennis Città di Perugia – Singles

Ulises Blanch was the defending champion but chose not to defend his title.

Federico Delbonis won the title after defeating Guillermo García López 6–0, 1–6, 7–6(7–5) in the final.

Seeds
All seeds receive a bye into the second round. • # 🇦🇷 Federico Delbonis (champion)

• # 🇧🇦 Damir Džumhur (second round)

• # 🇪🇸 Albert Ramos Viñolas (semifinals)

• # 🇮🇹 Paolo Lorenzi (third round)

• # Pedro Sousa (third round)

• # 🇮🇹 Salvatore Caruso (second round)

• # 🇮🇹 Filippo Baldi (second round, retired)

• # 🇮🇹 Alessandro Giannessi (quarterfinals, retired)

• # 🇦🇷 Facundo Bagnis (third round, retired)

• # 🇪🇸 Guillermo García López (final)

• # 🇮🇹 Federico Gaio (quarterfinals)

• # 🇦🇷 Federico Coria (third round)

• # 🇮🇹 Stefano Napolitano (third round)

• # 🇸🇰 Filip Horanský (second round)

• # 🇪🇨 Emilio Gómez (third round)

• # 🇨🇴 Daniel Elahi Galán (semifinals)