2020–21 OFI Crete F.C. season

The 2020–21 OFI Crete F.C. season was the club's 96th season in existence and the third consecutive season in the top flight of Greek football. In addition to the domestic league, OFI participated in this season's editions of the Greek Football Cup and the UEFA Europa League. The season covered the period from 20 July 2020 to 30 June 2021.