2021–22 FC Porto season

The 2021–22 season was the 128th season in the existence of FC Porto and the club's 88th consecutive season in the top flight of Portuguese football. In addition to the domestic league, Porto participated in this season's editions of the Taça de Portugal, the Taça da Liga, the UEFA Champions League and the UEFA Europa League.

Technical staff
{| class=wikitable !Position !Staff Vedran Runje
 * Head coach || Sérgio Conceição
 * rowspan=2| Assistant coaches || Vítor Bruno
 * 🇫🇷 Siramana Dembélé
 * Goalkeeper coaches || Diamantino Figueiredo
 * 🇫🇷 Siramana Dembélé
 * Goalkeeper coaches || Diamantino Figueiredo
 * Goalkeeper coaches || Diamantino Figueiredo
 * Goalkeeper coaches || Diamantino Figueiredo
 * Exercise Physiologist|| Eduardo Oliveira
 * Fitness coach|| Telmo Sousa
 * Fitness coach|| Telmo Sousa
 * Fitness coach|| Telmo Sousa

Third round
 

Group stage
The draw for the group stage was held on 26 August 2021.

Knockout round play-offs
The draw for the knockout round play-offs was held on 13 December 2021. 

Round of 16
The draw for the round of 16 was held on 25 February 2022.

Appearances and goals
! colspan=18 style=background:#dcdcdc; text-align:center|Goalkeepers

! colspan=18 style=background:#dcdcdc; text-align:center|Defenders

! colspan=18 style=background:#dcdcdc; text-align:center|Midfielders

! colspan=18 style=background:#dcdcdc; text-align:center|Forwards

! colspan=18 style=background:#dcdcdc; text-align:center|Players who made an appearance and/or had a squad number but left the team.


 * }