2021 Biella Challenger VI – Singles

Juan Pablo Varillas was the defending champion but chose not to defend his title.

Thanasi Kokkinakis won the title after defeating Enzo Couacaud 6–3, 6–4 in the final.

Seeds
• # 🇮🇹 Paolo Lorenzi (first round)

• # 🇨🇳 Zhang Zhizhen (semifinals)

• # 🇫🇷 Enzo Couacaud (final)

• # 🇫🇷 Alexandre Müller (quarterfinals)

• # 🇰🇿 Dmitry Popko (first round)

• # 🇦🇺 Alex Bolt (first round)

• # 🇧🇷 João Menezes (first round)

• # 🇺🇸 Bjorn Fratangelo (quarterfinals)