2021 Boar's Head Resort Women's Open – Singles

Whitney Osuigwe was the defending champion, having won the last edition in 2019 but retired in the first round against Arianne Hartono.

Claire Liu won the title after Wang Xinyu retired in the final at 3–6, 6–4, 4–1.

Seeds
• # 🇺🇸 Madison Brengle (first round, retired)

• # 🇪🇬 Mayar Sherif (second round)

• # 🇺🇸 Kristie Ahn (first round)

• # 🇷🇴 Irina Bara (second round)

• # 🇧🇾 Olga Govortsova (first round)

• # 🇨🇳 Wang Xinyu (final, retired)

• # 🇬🇧 Harriet Dart (quarterfinals, withdrew)

• # 🇵🇱 Magdalena Fręch (first round)