2021 Challenger de Santiago – Doubles

Franco Agamenone and Fernando Romboli were the defending champions but chose not to defend their title.

Luis David Martínez and Gonçalo Oliveira won the title after defeating Rafael Matos and Felipe Meligeni Alves 7–5, 6–1 in the final.

Seeds
• # 🇻🇪 Luis David Martínez / Gonçalo Oliveira (champions)

• # 🇧🇷 Rafael Matos / 🇧🇷 Felipe Meligeni Alves (final)

• # 🇵🇪 Sergio Galdós / 🇦🇷 Facundo Mena (semifinals)

• # 🇧🇷 Orlando Luz / 🇦🇷 Renzo Olivo (first round)