2021 Challenger de Santiago

The 2021 Challenger de Santiago was a professional tennis tournament played on clay courts. It was the 13th edition of the tournament which was part of the 2021 ATP Challenger Tour. It took place in Santiago, Chile between 15 and 21 March 2021.

Seeds

 * 1 Rankings are as of 8 March 2021.

Other entrants
The following players received wildcards into the singles main draw:
 * Nicolás Jarry
 * Gonzalo Lama
 * Holger Rune

The following player received entry into the singles main draw as an alternate:
 * 🇦🇷 Camilo Ugo Carabelli

The following players received entry from the qualifying draw:
 * Martín Cuevas
 * 🇦🇷 Nicolás Kicker
 * 🇧🇷 João Menezes
 * 🇦🇷 Gonzalo Villanueva

The following player received entry as a lucky loser:
 * 🇧🇷 Rafael Matos

Singles

 * 🇦🇷 Sebastián Báez def. Marcelo Tomás Barrios Vera 6–3, 7–6(7–4).

Doubles

 * 🇻🇪 Luis David Martínez / Gonçalo Oliveira def. 🇧🇷 Rafael Matos / 🇧🇷 Felipe Meligeni Alves 7–5, 6–1.