2021 Henderson Tennis Open – Singles

Mayo Hibi was the defending champion but chose to compete at the 2021 BNP Paribas Open instead.

Emina Bektas won the title, defeating Yuriko Lily Miyazaki in the final, 6–1, 6–1.

Seeds
• # Conny Perrin (first round)

• # 🇺🇸 Allie Kiick (quarterfinals)

• # 🇯🇵 Yuriko Lily Miyazaki (final)

• # 🇺🇸 Hanna Chang (semifinals)

• # 🇺🇸 Alexa Glatch (first round)

• # 🇺🇸 Emina Bektas (champion)

• # Lulu Sun (second round)

• # 🇯🇵 Nagi Hanatani (first round)