2021 Las Vegas Challenger – Singles

Vasek Pospisil was the defending champion but chose not to defend his title.

J. J. Wolf won the title after defeating Stefan Kozlov 6–4, 6–4 in the final.

Seeds
• # 🇺🇸 Steve Johnson (first round)

• # 🇺🇸 Denis Kudla (second round)

• # 🇺🇸 Tennys Sandgren (first round, retired)

• # 🇩🇪 Daniel Altmaier (second round)

• # 🇯🇵 Taro Daniel (quarterfinals)

• # 🇺🇸 Mitchell Krueger (first round)

• # 🇪🇨 Emilio Gómez (quarterfinals)

• # Jason Jung (first round)