2021 Little Rock Challenger – Singles

Dudi Sela was the defending champion but chose not to defend his title.

Jack Sock won the title after defeating Emilio Gómez 7–5, 6–4 in the final.

Seeds
• # Jason Jung (quarterfinals)

• # 🇺🇸 Michael Mmoh (withdrew)

• # 🇪🇨 Emilio Gómez (final)

• # 🇺🇸 Ernesto Escobedo (second round)

• # 🇺🇸 Mitchell Krueger (semifinals)

• # 🇺🇸 Thai-Son Kwiatkowski (quarterfinals)

• # 🇩🇴 Roberto Cid Subervi (first round)

• # 🇺🇸 Christopher Eubanks (second round)

• # 🇨🇦 Peter Polansky (first round)