2021 Orlando Open – Singles

Brandon Nakashima was the defending champion but chose not to defend his title.

Jenson Brooksby won the title after defeating Denis Kudla 6–3, 6–3 in the final.

Seeds
• # 🇺🇸 Steve Johnson (first round)

• # 🇯🇵 Yasutaka Uchiyama (second round)

• # 🇺🇸 Mackenzie McDonald (first round)

• # 🇧🇷 Thiago Seyboth Wild (second round)

• # 🇺🇸 Denis Kudla (final)

• # 🇮🇳 Prajnesh Gunneswaran (second round)

• # Jason Jung (first round)

• # Alejandro Tabilo (first round)