2021 Portugal Ladies Open – Singles

Isabella Shinikova was the defending champion but chose to compete at the 2021 BGL Luxembourg Open instead.

Zheng Saisai won the title, defeating Harmony Tan in the final, 6–4, 3–6, 6–3.

Seeds
• # 🇨🇳 Zheng Saisai

• # 🇨🇳 Wang Xinyu (quarterfinals)

• # 🇫🇷 Harmony Tan (final)

• # 🇦🇺 Maddison Inglis (semifinals)

• # 🇦🇺 Arina Rodionova (first round)

• # 🇦🇺 Lizette Cabrera (first round)

• # 🇧🇷 Beatriz Haddad Maia (semifinals)

• # 🇺🇦 Daria Snigur (first round)