2021 Wiesbaden Tennis Open – Singles

Barbora Krejčíková was the defending champion but chose not to participate.

Anna Bondár won the title, defeating Clara Burel in the final, 6–2, 6–4.

Seeds
• # 🇫🇷 Clara Burel (final)

• # 🇪🇸 Cristina Bucșa (first round)

• # 🇭🇺 Anna Bondár (champion)

• # 🇷🇺 Marina Melnikova (second round)

• # 🇭🇺 Réka Luca Jani (first round)

• # 🇮🇹 Giulia Gatto-Monticone (second round)

• # 🇮🇹 Lucrezia Stefanini (quarterfinals)

• # 🇮🇹 Federica Di Sarra (quarterfinals, retired)