2022 Columbus Challenger – Singles

Stefan Kozlov was the defending champion but lost in the second round to Dominic Stricker.

Yoshihito Nishioka won the title after defeating Stricker 6–2, 6–4 in the final.

Seeds
• # 🇺🇸 Jenson Brooksby (semifinals)

• # 🇺🇸 Tennys Sandgren (first round)

• # 🇯🇵 Yoshihito Nishioka (champion)

• # 🇦🇹 Jurij Rodionov (semifinals)

• # 🇺🇸 Ernesto Escobedo (quarterfinals)

• # 🇪🇨 Emilio Gómez (quarterfinals)

• # 🇺🇸 Jack Sock (quarterfinals, withdrew)

• # 🇺🇸 Bjorn Fratangelo (second round)