2021 Columbus Challenger – Men's singles

J. J. Wolf was the defending champion but lost in the semifinals to Stefan Kozlov.

Kozlov won the title after defeating Max Purcell 4–6, 6–2, 6–4 in the final.

Seeds
• # 🇺🇸 Tennys Sandgren (quarterfinals)

• # 🇮🇹 Salvatore Caruso (first round, retired)

• # 🇦🇺 Alex Bolt (quarterfinals)

• # 🇮🇳 Prajnesh Gunneswaran (second round)

• # Jason Jung (first round)

• # 🇺🇸 Ernesto Escobedo (first round)

• # 🇺🇸 J. J. Wolf (semifinals)

• # 🇺🇸 Mitchell Krueger (first round)