2022 Guanajuato Open – Singles

Zhu Lin won the title, defeating Rebecca Marino in the final, 6–4, 6–1.

Astra Sharma was the defending champion having won the event when it was last held in 2019, but chose to participate at the BNP Paribas Open, where she reached the second round as a lucky loser.

Seeds
• # 🇨🇳 Zhu Lin (champion)

• # 🇨🇦 Rebecca Marino (final)

• # Anastasia Gasanova (withdrew)

• # Arianne Hartono (second round)

• # 🇺🇸 Robin Anderson (second round)

• # 🇸🇪 Mirjam Björklund (withdrew)

• # Valentini Grammatikopoulou (second round)

• # 🇺🇸 Jamie Loeb (quarterfinals)