2022 Iași Open – Men's singles

Zdeněk Kolář was the defending champion but retired from his first round match with Frederico Ferreira Silva.

Felipe Meligeni Alves won the title after defeating Pablo Andújar 6–3, 4–6, 6–2 in the final.

Seeds
• # 🇨🇿 Jiří Lehečka (quarterfinals)

• # 🇪🇸 Pablo Andújar (final)

• # 🇨🇿 Zdeněk Kolář (first round, retired)

• # Alexander Shevchenko (first round)

• # 🇫🇷 Geoffrey Blancaneaux (quarterfinals)

• # 🇨🇿 Dalibor Svrčina (second round)

• # 🇦🇷 Renzo Olivo (first round)

• # 🇧🇷 Felipe Meligeni Alves (champion)