2022 Internazionali di Tennis Città di Perugia – Singles

Tomás Martín Etcheverry was the defending champion but lost in the final to Jaume Munar.

Munar won the title after defeating Etcheverry 6–3, 4–6, 6–1 in the final.

Seeds
• # 🇪🇸 Carlos Taberner (first round)

• # 🇪🇸 Jaume Munar (champion)

• # 🇦🇷 Tomás Martín Etcheverry (final)

• # 🇪🇸 Roberto Carballés Baena (second round, retired)

• # 🇧🇷 Thiago Monteiro (quarterfinals)

• # 🇨🇴 Daniel Elahi Galán (first round)

• # 🇮🇹 Gianluca Mager (first round)

• # 🇵🇪 Juan Pablo Varillas (first round)