2022 São Paulo FC season

The 2022 season was São Paulo's 93rd season in the club's history and their 62nd in the top-flight of Brazilian football. Along with Série A, São Paulo competed in the Campeonato Paulista, Copa do Brasil and Copa Sudamericana.

Retired numbers

 * 01 – 🇧🇷 Rogério Ceni, Goalkeeper (1990–2015)

Overall
{|class="wikitable"
 * Games played || 77 (16 Campeonato Paulista, 10 Copa do Brasil, 13 Copa Sudamericana, 38 Campeonato Brasileiro)
 * Games won || 36 (10 Campeonato Paulista, 4 Copa do Brasil, 9 Copa Sudamericana, 13 Campeonato Brasileiro)
 * Games drawn || 21 (2 Campeonato Paulista, 3 Copa do Brasil, 1 Copa Sudamericana, 15 Campeonato Brasileiro)
 * Games lost || 20 (4 Campeonato Paulista, 3 Copa do Brasil, 3 Copa Sudamericana, 10 Campeonato Brasileiro)
 * Goals scored || 119
 * Goals conceded || 82
 * Goal difference || +37
 * Best results (goal difference) || 4–0 (H) v Athletico Paranaense - Campeonato Brasileiro - 2022.04.10 4–0 (H) v Avaí - Campeonato Brasileiro - 2022.09.25 4–0 (A) v Goiás - Campeonato Brasileiro - 2022.11.13
 * Worst result (goal difference)|| 0–4 (A) v Palmeiras - Campeonato Paulista - 2022.04.03
 * Top scorer || Jonathan Calleri (27 goals)
 * Goals conceded || 82
 * Goal difference || +37
 * Best results (goal difference) || 4–0 (H) v Athletico Paranaense - Campeonato Brasileiro - 2022.04.10 4–0 (H) v Avaí - Campeonato Brasileiro - 2022.09.25 4–0 (A) v Goiás - Campeonato Brasileiro - 2022.11.13
 * Worst result (goal difference)|| 0–4 (A) v Palmeiras - Campeonato Paulista - 2022.04.03
 * Top scorer || Jonathan Calleri (27 goals)
 * Best results (goal difference) || 4–0 (H) v Athletico Paranaense - Campeonato Brasileiro - 2022.04.10 4–0 (H) v Avaí - Campeonato Brasileiro - 2022.09.25 4–0 (A) v Goiás - Campeonato Brasileiro - 2022.11.13
 * Worst result (goal difference)|| 0–4 (A) v Palmeiras - Campeonato Paulista - 2022.04.03
 * Top scorer || Jonathan Calleri (27 goals)
 * Top scorer || Jonathan Calleri (27 goals)
 * Top scorer || Jonathan Calleri (27 goals)

Copa Sudamericana
The draw for the group stage was held on 25 March 2022, 12:00 PYST (UTC−4), at the CONMEBOL Convention Centre in Luque, Paraguay.

Round of 16
The draw for the round of 16 was held on 27 May 2022, 12:00 PYST (UTC−4), at the CONMEBOL Convention Centre in Luque, Paraguay.

Matches
The league fixtures were announced on 2 February 2022.