2022 San Luis Open Challenger – Doubles

Marcelo Arévalo and Miguel Ángel Reyes-Varela were the defending champions but only Reyes-Varela chose to defend his title, partnering Nicolás Barrientos. Reyes-Varela successfully defended his title, defeating Luis David Martínez and Felipe Meligeni Alves 7–6(13–11), 6–2 in the final.

Seeds
• # 🇨🇴 Nicolás Barrientos / 🇲🇽 Miguel Ángel Reyes-Varela (champions)

• # 🇻🇪 Luis David Martínez / 🇧🇷 Felipe Meligeni Alves (final)

• # 🇸🇰 Andrej Martin / 🇦🇹 Tristan-Samuel Weissborn (semifinals)

• # Gonçalo Oliveira / 🇮🇳 Divij Sharan (first round)