2022 San Luis Open Challenger

The 2022 San Luis Open Challenger was a professional tennis tournament played on clay courts. It was the 27th edition of the tournament which was part of the 2022 ATP Challenger Tour. It took place in San Luis Potosí, Mexico between 11 and 17 April 2022.

Seeds

 * 1 Rankings are as of 4 April 2022.

Other entrants
The following players received wildcards into the singles main draw:
 * 🇲🇽 Alex Hernández
 * 🇯🇵 Shintaro Mochizuki
 * 🇲🇽 Rodrigo Pacheco Méndez

The following players received entry into the singles main draw as alternates:
 * 🇳🇴 Viktor Durasovic
 * 🇷🇸 Peđa Krstin

The following players received entry from the qualifying draw:
 * Antoine Bellier
 * Hady Habib
 * 🇧🇷 Gilbert Klier Júnior
 * 🇪🇨 Roberto Quiroz
 * 🇨🇳 Shang Juncheng
 * 🇦🇷 Matías Zukas

Singles

 * Antoine Bellier def. 🇦🇷 Renzo Olivo 6–7(2–7), 6–4, 7–5.

Doubles

 * 🇨🇴 Nicolás Barrientos / 🇲🇽 Miguel Ángel Reyes-Varela def. 🇻🇪 Luis David Martínez / 🇧🇷 Felipe Meligeni Alves 7–6(13–11), 6–2.