2022 South Dakota Coyotes football team

The 2022 South Dakota Coyotes football team represented the University of South Dakota in the 2022 NCAA Division I FCS football season. The Coyotes competed as members of the Missouri Valley Football Conference and were led by seventh-year head coach Bob Nielson. They played their home games at the DakotaDome in Vermillion, South Dakota.

At Kansas State
South Dakota did not hold up against Kansas State, failing to score the entire game. South Dakota gave up a blocked punt that the Wildcats turned into a touchdown, couldn't stop what was called an "impressive" ground game, and gave up a touchdown in the first ten seconds. South Dakota did hold Kansas State to just 96 passing yards. Kansas State won the game 34-0.